Format

Send to:

Choose Destination

NEU3 neuraminidase 3 (membrane sialidase) [ Homo sapiens (human) ]

Gene ID: 10825, updated on 8-May-2016
Official Symbol
NEU3provided by HGNC
Official Full Name
neuraminidase 3 (membrane sialidase)provided by HGNC
Primary source
HGNC:HGNC:7760
See related
Ensembl:ENSG00000162139 HPRD:05215; MIM:604617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAL3
Summary
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q13.5
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (74988905..75007698)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74699950..74718743)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene signal peptidase complex subunit 2 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 50

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Removal of sialic acids from HIV-1 gp120 with neuraminidase (NA) enhances mannose-binding lectin (MBL) binding PubMed
env The desialylation of HIV-1 gp120 with neuraminidase greatly augments the initial virus-cell interaction, leading to remarkably enhanced viral replication and cytopathogenicity PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-(2->3)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
exo-alpha-(2->8)-sialidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
exo-alpha-sialidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
sialidase-3
Names
N-acetyl-alpha-neuraminidase 3
ganglioside sialidase
membrane sialidase
neuraminidase 3
sialidase 3 (membrane sialidase)
NP_006647.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006656.5NP_006647.3  sialidase-3

    See identical proteins and their annotated locations for NP_006647.3

    Status: REVIEWED

    Source sequence(s)
    AP001992, CN429425, DB240271
    Consensus CDS
    CCDS44682.1
    UniProtKB/Swiss-Prot
    Q9UQ49
    UniProtKB/TrEMBL
    A0A024R5N6
    Related
    ENSP00000294064, OTTHUMP00000230036, ENST00000294064, OTTHUMT00000384595
    Conserved Domains (2) summary
    pfam13088
    Location:70417
    BNR_2; BNR repeat-like domain
    cd15482
    Location:44436
    Sialidase_non-viral; Non-viral sialidases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    74988905..75007698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    74583347..74602139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)