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Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) [ Mus musculus (house mouse) ]

Gene ID: 108155, updated on 28-May-2016
Official Symbol
Ogtprovided by MGI
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)provided by MGI
Primary source
MGI:MGI:1339639
See related
Ensembl:ENSMUSG00000034160 Vega:OTTMUSG00000017263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ogtl; AI115525; 1110038P24Rik; 4831420N21Rik
Orthologs
Location:
X; X D
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (101640012..101684351)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (98835403..98879690)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 26 pseudogene Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene RNA binding protein pseudogene Neighboring gene predicted gene, 31444

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone acetyltransferase activity (H4-K16 specific) ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone acetyltransferase activity (H4-K5 specific) ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone acetyltransferase activity (H4-K8 specific) ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
protein O-GlcNAc transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein O-GlcNAc transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein O-GlcNAc transferase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
histone H3-K4 trimethylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
 
intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H3-K27 methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
protein heterotrimerization ISO
Inferred from Sequence Orthology
more info
 
protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of gluconeogenesis involved in cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MLL5-L complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
euchromatin ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
intracellular TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
zymogen granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine transferase 110 kDa subunit
NP_001277464.1
NP_631883.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290535.1NP_001277464.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    See identical proteins and their annotated locations for NP_001277464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK045910, BC057319, CB520299, CD544482
    Consensus CDS
    CCDS72415.1
    UniProtKB/Swiss-Prot
    Q8CGY8
    Conserved Domains (8) summary
    cd05804
    Location:110270
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    COG0457
    Location:194451
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam00515
    Location:79112
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:79144
    TPR_11; TPR repeat
    pfam13424
    Location:149213
    TPR_12; Tetratricopeptide repeat
    pfam13844
    Location:5461014
    Glyco_transf_41; Glycosyl transferase family 41
    cl19051
    Location:269453
    ST7; Suppression of tumorigenicity 7
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
  2. NM_139144.4NP_631883.2  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_631883.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK045910, BC057319, BY196484, CF166269
    Consensus CDS
    CCDS30318.1
    UniProtKB/Swiss-Prot
    Q8CGY8
    Related
    ENSMUSP00000045409, OTTMUSP00000019749, ENSMUST00000044475, OTTMUST00000043983
    Conserved Domains (8) summary
    cd05804
    Location:120280
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    COG0457
    Location:204461
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam00515
    Location:89122
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:89154
    TPR_11; TPR repeat
    pfam13424
    Location:159223
    TPR_12; Tetratricopeptide repeat
    pfam13844
    Location:5561024
    Glyco_transf_41; Glycosyl transferase family 41
    cl19051
    Location:279463
    ST7; Suppression of tumorigenicity 7
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    101640012..101684351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527736.2XP_006527799.1  

    See identical proteins and their annotated locations for XP_006527799.1

    UniProtKB/Swiss-Prot
    Q8CGY8
    Conserved Domains (8) summary
    cd05804
    Location:120280
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    COG0457
    Location:204461
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam00515
    Location:89122
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:89154
    TPR_11; TPR repeat
    pfam13424
    Location:159223
    TPR_12; Tetratricopeptide repeat
    pfam13844
    Location:5561024
    Glyco_transf_41; Glycosyl transferase family 41
    cl19051
    Location:279463
    ST7; Suppression of tumorigenicity 7
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
  2. XM_011247503.1XP_011245805.1  

    See identical proteins and their annotated locations for XP_011245805.1

    UniProtKB/Swiss-Prot
    Q8CGY8
    Related
    ENSMUSP00000113454, OTTMUSP00000019750, ENSMUST00000119299, OTTMUST00000043984
    Conserved Domains (8) summary
    cd05804
    Location:110270
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    COG0457
    Location:194451
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam00515
    Location:79112
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:79144
    TPR_11; TPR repeat
    pfam13424
    Location:149213
    TPR_12; Tetratricopeptide repeat
    pfam13844
    Location:5461014
    Glyco_transf_41; Glycosyl transferase family 41
    cl19051
    Location:269453
    ST7; Suppression of tumorigenicity 7
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    88557707..88602477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)