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    HSPH1 heat shock 105kDa/110kDa protein 1 [ Homo sapiens (human) ]

    Gene ID: 10808, updated on 14-May-2013
    Official Symbol
    HSPH1provided by HGNC
    Official Full Name
    heat shock 105kDa/110kDa protein 1provided by HGNC
    Primary source
    HGNC:16969
    Locus tag
    RP11-173P16.1
    See related
    Ensembl:ENSG00000120694; HPRD:09990; MIM:610703; Vega:OTTHUMG00000016685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP105; HSP105A; HSP105B; NY-CO-25
    Location :
    13q12.3
    Sequence :
    Chromosome: 13; NC_000013.10 (31710762..31736117, complement)
    See HSPH1 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene testis expressed 26 Neighboring gene WD40 repeat domain 95, pseudogene Neighboring gene beta 1,3-galactosyltransferase-like Neighboring gene ankyrin repeat domain 26 pseudogene 4 Neighboring gene relaxin/insulin-like family peptide receptor 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Foster MW, et al. Nitric Oxide, 2013 Feb 21. PMID 23438482.
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013 Jan. PMID 23349634.
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    5. Prevalence and pathogenesis of Barrett's esophagus in Luoyang, China. Zhang RG, et al. Asian Pac J Cancer Prev, 2012. PMID 22901192.

    See all (59) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. High HSP105 expression is associated with Barrett's esophagus.
      Title: Prevalence and pathogenesis of Barrett's esophagus in Luoyang, China.
    2. It restricts aggregation of denaturated proteins,plays a role in protein folding in cytoplasms,and enhance expression of hsp70 in cell nucleus.(review)
      Title: [Structure and function of HSP105 family proteins].
    3. The Hsp105-mediated multilevel regulation of DeltaF508 CFTR folding and quality control provides new opportunities to understand how chaperone machinery regulates the homeostasis and functional expression of misfolded proteins in the cell.
      Title: Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels.
    4. A direct correlation between HSP105 expression and lymphoma aggressiveness was also apparent.
      Title: Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target.
    5. Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70.
      Title: Hsp105 reduces the protein aggregation and cytotoxicity by expanded-polyglutamine proteins through the induction of Hsp70.
    6. HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70.
      Title: Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi.
    7. HSP105 analysis may be a helpful tool as a poor prognostic indicator and as a diagnostic aid in problematic lesions.
      Title: Differential expression of heat shock protein 105 in melanoma and melanocytic naevi.
    8. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process.
      Title: HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.
    9. Heat shock protein 105 is overexpressed in a variety of human tumors
      Title: Heat shock protein 105 is overexpressed in a variety of human tumors.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env HIV-1 gp160 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q92598 P35611 ADD1    HPRD  PubMed  
    Q92598 P23528 CFL1    HPRD  PubMed  
    Q92598 Q12873 CHD3    HPRD  PubMed  
    Q92598 P68400 CSNK2A1    HPRD  PubMed  
    Q92598 P19784 CSNK2A2    HPRD  PubMed  
    Q92598 P11142 HSPA8    HPRD  PubMed  
    Q92598 P43034 PAFAH1B1    HPRD  PubMed  
    Q92598 P00558 PGK1    HPRD  PubMed  
    Q92598 P68366 TUBA4A    HPRD  PubMed  
    Q92598 P22314 UBA1    HPRD  PubMed  
    BioGRID:116022 BioGRID:106631 ADD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:116022 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:197981 Add1    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:118894 BLNK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:107499 CFL1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:116022 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:107971 DAB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:108142 DPYSL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:123715 DYNLRB1    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:115367 FARSB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:114053 HIRIP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:127352 METTL21A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:110906 NOS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116022 BioGRID:120860 PARVA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:111251 PGK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116022 BioGRID:111367 PLOD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:111491 PPM1G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:115491 PRMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:120011 PUS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:202017 Pafah1b3    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:202133 Pgk1    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:114070 RANBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:128652 RPLP0P6    BioGRID  PubMed Co-fractionation 
    BioGRID:116022 BioGRID:117436 SAMHD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:115747 SEC23A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:112316 SET    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:113368 SF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:118159 STK39    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:113165 UBA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116022 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:113207 UGP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:204410 Uba1    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:113253 VAV2    BioGRID  PubMed Two-hybrid 
    BioGRID:116022 BioGRID:116678 XPO7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:119242 ZBTB7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116022 BioGRID:1205544 env    BioGRID  PubMed Affinity Capture-MS 
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA0201, DKFZp686M05240

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    chaperone mediated protein folding requiring cofactor IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MHC class I biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of NK T cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to unfolded protein TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    heat shock protein 105 kDa
    Names
    heat shock protein 105 kDa
    antigen NY-CO-25
    heat shock 105kD beta
    heat shock 105kD alpha
    heat shock 110 kDa protein
    heat shock 105kDa protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006644.2 → NP_006635.2  heat shock protein 105 kDa

      Status: VALIDATED

      Source sequence(s)
      BC037553, CD251908
      Consensus CDS
      CCDS9340.1
      UniProtKB/Swiss-Prot
      Q92598
      Related
      ENSP00000318687, OTTHUMP00000018208, ENST00000320027, OTTHUMT00000044384
      Conserved Domains (2) summary
      pfam00012
      Location:3 – 624
      Blast Score: 1515
      HSP70; Hsp70 protein
      cd11739
      Location:2 – 384
      Blast Score: 2025
      HSPH1_NBD; Nucleotide-binding domain of HSPH1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p10 Primary Assembly

      Range
      31710762..31736117, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      12522150..12547508, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018924.1 Alternate CHM1_1.0

      Range
      12660188..12685541, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01010121.1 (70263..95621) None
    genomic AL137142.20 (37672..63027) None
    genomic AMYH01005013.1 (231679..257032) None
    genomic CH471075.1 EAX08477.1
      EAX08478.1
      EAX08479.1
      EAX08480.1
      EAX08481.1
      EAX08482.1
    mRNA AB003333.1 BAA34779.1
    mRNA AB003334.1 BAA34780.1
    mRNA AF039695.1 AAC18044.1
    mRNA AK293955.1 BAG57329.1
    mRNA AK302294.1 BAG63634.1
    mRNA AK302430.1 BAG63733.1
    mRNA AK302832.1 BAG64026.1
    mRNA AK303029.1 BAG64155.1
    mRNA AK307597.1 None
    mRNA AK311464.1 None
    mRNA AK314576.1 None
    mRNA BC018124.2 None
    mRNA BC037553.1 AAH37553.1
    mRNA BX648125.1 None
    mRNA BX648623.1 None
    mRNA CD251908.1 None
    mRNA D86956.1 BAA13192.2
    other-genetic DQ891727.2 ABM82653.1
    other-genetic DQ894904.2 ABM85830.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92598.1 GenPept UniProtKB/Swiss-Prot:Q92598

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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