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HSPH1 heat shock 105kDa/110kDa protein 1 [ Homo sapiens (human) ]

Gene ID: 10808, updated on 17-Apr-2014
Official Symbol
HSPH1provided by HGNC
Official Full Name
heat shock 105kDa/110kDa protein 1provided by HGNC
Primary source
HGNC:16969
Locus tag
RP11-173P16.1
See related
Ensembl:ENSG00000120694; HPRD:09990; MIM:610703; Vega:OTTHUMG00000016685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP105; HSP105A; HSP105B; NY-CO-25
Location :
13q12.3
Sequence :
Chromosome: 13; NC_000013.11 (31134974..31163109, complement)
See HSPH1 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723392 Neighboring gene WD repeat domain 95, pseudogene Neighboring gene beta 1,3-galactosyltransferase-like Neighboring gene ankyrin repeat domain 26 pseudogene 4 Neighboring gene relaxin/insulin-like family peptide receptor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env HIV-1 gp160 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Scavenging by Class F Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class F Receptors, organism-specific biosystemSCARF1 (SREC-I) and SCARF2 (SREC-II) are transmembrane proteins that contain multiple extracellular EGF-like domains (Ishii et al. 2002, reviewed in Areschoug and Gordon 2009). SCARF2 may be involved...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
heat shock protein 105 kDa
Names
heat shock protein 105 kDa
antigen NY-CO-25
heat shock 105kD beta
heat shock 105kD alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286503.1NP_001273432.1  heat shock protein 105 kDa isoform 2

    See proteins identical to NP_001273432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB003333, AL137142, BC037553, DB077644
    Consensus CDS
    CCDS66525.1
    UniProtKB/Swiss-Prot
    Q92598
    Conserved Domains (2) summary
    cd11739
    Location:2384
    Blast Score: 2067
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3664
    Blast Score: 1623
    HSP70; Hsp70 protein
  2. NM_001286504.1NP_001273433.1  heat shock protein 105 kDa isoform 3

    See proteins identical to NP_001273433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK302430, AL137142, BC037553, DB069199
    Consensus CDS
    CCDS66526.1
    UniProtKB/TrEMBL
    B4DYH1
    UniProtKB/Swiss-Prot
    Q92598
    Conserved Domains (2) summary
    pfam00012
    Location:39710
    Blast Score: 1451
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    Blast Score: 1889
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001286505.1NP_001273434.1  heat shock protein 105 kDa isoform 4

    See proteins identical to NP_001273434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK302294, AK302430, AL137142, BC037553, DB069199
    UniProtKB/TrEMBL
    B4DY72
    UniProtKB/TrEMBL
    B4DYH1
    UniProtKB/Swiss-Prot
    Q92598
    Conserved Domains (2) summary
    pfam00012
    Location:39632
    Blast Score: 1088
    HSP70; Hsp70 protein
    cl17037
    Location:39308
    Blast Score: 1353
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_006644.3NP_006635.2  heat shock protein 105 kDa isoform 1

    See proteins identical to NP_006635.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AL137142, BC037553, CD251908, DB077644
    Consensus CDS
    CCDS9340.1
    UniProtKB/Swiss-Prot
    Q92598
    Related
    ENSP00000318687, OTTHUMP00000018208, ENST00000320027, OTTHUMT00000044384
    Conserved Domains (2) summary
    cd11739
    Location:2384
    Blast Score: 2067
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3708
    Blast Score: 1580
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11

    Range
    31134974..31163109, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266236.1XP_005266293.1  

    Conserved Domains (2) summary
    pfam00012
    Location:39666
    Blast Score: 1494
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    Blast Score: 1889
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_006719757.1XP_006719820.1  

    Conserved Domains (2) summary
    cd11739
    Location:71439
    Blast Score: 2002
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:71763
    Blast Score: 1536
    HSP70; Hsp70 protein

Alternate HuRef

Genomic

  1. AC_000145.1 Alternate HuRef

    Range
    12520499..12547916, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    31676685..31704097, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

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