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HSPH1 heat shock 105kDa/110kDa protein 1 [ Homo sapiens (human) ]

Gene ID: 10808, updated on 18-Jul-2015
Official Symbol
HSPH1provided by HGNC
Official Full Name
heat shock 105kDa/110kDa protein 1provided by HGNC
Primary source
HGNC:HGNC:16969
See related
Ensembl:ENSG00000120694; HPRD:09990; MIM:610703; Vega:OTTHUMG00000016685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP105; HSP105A; HSP105B; NY-CO-25
Orthologs
See HSPH1 in Epigenomics, MapViewer
Location:
13q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (31134974..31163109, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31710762..31737246, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723392 Neighboring gene WD repeat domain 95, pseudogene Neighboring gene uncharacterized LOC105370148 Neighboring gene beta 3-glucosyltransferase Neighboring gene ankyrin repeat domain 26 pseudogene 4 Neighboring gene uncharacterized LOC105370149

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
  • Scavenging by Class F Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class F Receptors, organism-specific biosystemSCARF1 (SREC-I) and SCARF2 (SREC-II) are transmembrane proteins that contain multiple extracellular EGF-like domains (Ishii et al. 2002, reviewed in Areschoug and Gordon 2009). SCARF2 may be involved...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0201, DKFZp686M05240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
heat shock protein 105 kDa
Names
antigen NY-CO-25
heat shock 105kD alpha
heat shock 105kD beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286503.1NP_001273432.1  heat shock protein 105 kDa isoform 2

    See identical proteins and their annotated locations for NP_001273432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB003333, AL137142, BC037553, DB077644
    Consensus CDS
    CCDS66525.1
    UniProtKB/TrEMBL
    A0A024RDQ0
    UniProtKB/Swiss-Prot
    Q92598
    Conserved Domains (2) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3664
    HSP70; Hsp70 protein
  2. NM_001286504.1NP_001273433.1  heat shock protein 105 kDa isoform 3

    See identical proteins and their annotated locations for NP_001273433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK302430, AL137142, BC037553, DB069199
    Consensus CDS
    CCDS66526.1
    UniProtKB/Swiss-Prot
    Q92598
    Conserved Domains (2) summary
    pfam00012
    Location:39710
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_001286505.1NP_001273434.1  heat shock protein 105 kDa isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK302294, AK302430, AL137142, BC037553, DB069199
    Consensus CDS
    CCDS73559.1
    UniProtKB/TrEMBL
    A0A0A0MSM0
    UniProtKB/TrEMBL
    B4DY72
    UniProtKB/Swiss-Prot
    Q92598
    Related
    ENSP00000396090, ENST00000445273
    Conserved Domains (2) summary
    pfam00012
    Location:39632
    HSP70; Hsp70 protein
    cl17037
    Location:39308
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. NM_006644.3NP_006635.2  heat shock protein 105 kDa isoform 1

    See identical proteins and their annotated locations for NP_006635.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AL137142, BC037553, CD251908, DB077644
    Consensus CDS
    CCDS9340.1
    UniProtKB/TrEMBL
    A0A024RDS1
    UniProtKB/Swiss-Prot
    Q92598
    Related
    ENSP00000318687, OTTHUMP00000018208, ENST00000320027, OTTHUMT00000044384
    Conserved Domains (2) summary
    cd11739
    Location:2384
    HSPH1_NBD; Nucleotide-binding domain of HSPH1
    pfam00012
    Location:3708
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    31134974..31163109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266236.1XP_005266293.1  

    See identical proteins and their annotated locations for XP_005266293.1

    Related
    ENSP00000487365, OTTHUMP00000278728, ENST00000630972, OTTHUMT00000482781
    Conserved Domains (2) summary
    pfam00012
    Location:39666
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. XM_011534887.1XP_011533189.1  

    Conserved Domains (2) summary
    pfam00012
    Location:39710
    HSP70; Hsp70 protein
    cl17037
    Location:39386
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_011534888.1XP_011533190.1  

    Related
    ENSP00000369768, OTTHUMP00000018209, ENST00000380405, OTTHUMT00000044385
    Conserved Domains (2) summary
    pfam00012
    Location:3630
    HSP70; Hsp70 protein
    cl17037
    Location:2306
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    31676685..31704097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)