Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cdk9provided by MGI
Official Full Name: cyclin-dependent kinase 9 (CDC2-related kinase)provided by MGI
Primary source: MGI:1328368
Locus tag: RP23-17P12.6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PITALRE

Genomic context

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Location :: 2 B; 2

Sequence :: Chromosome: 2; NC_000068.7 (32705782..32712784, complement)

See Cdk9 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Title: Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Data show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.
Title: The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
The present study examined whether Cdk9 forms a complex with GATA4 in mouse embryonic stem cells and is involved in their differentiation into cardiomyocytes.
Title: Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.
Data report that a second cdk9 isoform, termed cdk9-55, plays a fundamental role in muscle regeneration and differentiation in vivo.
Title: Cdk9-55: a new player in muscle regeneration.
miR-1 and miR-133 may play significant roles in the myocardial differentiation of mouse ES cells, and Cdk9 may be involved in this process as a target of miR-1.
Title: MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.
As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of transcriptional mediator and elongation complexes.
Title: Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
In mice with megakaryocytic GATA-1 deficiency, Cdk9 inhibition produced a fulminant but reversible megakaryoblastic disorder reminiscent of the transient myeloproliferative disorder of Down syndrome.
Title: Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation.
These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.
Title: Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.
CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
Title: CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
role in activating MyoD-dependent transcription
Title: Activation of MyoD-dependent transcription by cdk9/cyclin T2.

Submit: New GeneRIF Correction See all (12)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:223714	BioGRID:106575	ACTB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:223714	BioGRID:107343	CCNT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:223714	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:223714	BioGRID:108896	GATA4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:223714	BioGRID:202815	Rb1	BioGRID	PubMed	Biochemical Activity
BioGRID:223714	BioGRID:204303	Traf2	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, organism-specific biosystem (from REACTOME)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
mRNA processing, organism-specific biosystem (from WikiPathways)
mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

General gene information

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Markers

AW821975 (e-PCR)
- UniSTS:207746

Cdk9 (e-PCR), detects polymorphism
- UniSTS:527281

Homology

Homologs of the Cdk9 gene: The Cdk9 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, and S.pombe.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
RNA polymerase II carboxy-terminal domain kinase activity	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info
cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
snRNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
negative regulation of cell cycle arrest	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
regulation of DNA repair	ISO Inferred from Sequence Orthology more info
regulation of histone modification	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
replication fork arrest	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
PML body	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
positive transcription elongation factor complex b	ISO Inferred from Sequence Orthology more info
positive transcription elongation factor complex b	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclin-dependent kinase 9

Names: cyclin-dependent kinase 9; cell division protein kinase 9

NP_570930.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130860.3 → NP_570930.1 cyclin-dependent kinase 9

Status: VALIDATED

Source sequence(s)

AK143217, AL772271

Consensus CDS

CCDS15927.1

UniProtKB/Swiss-Prot

Q99J95

Conserved Domains (2) summary

cd07865
Location:6 – 315
Blast Score: 1719

STKc_CDK9; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9

smart00220
Location:19 – 315
Blast Score: 693

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

32705782..32712784, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

32412389..32419391, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01015125.1 (30983..37985)	None
genomic	AF327569.1	AAK15706.1
genomic	AL772271.11 (120643..127645)	None
genomic	CH466542.1	EDL08566.1	mixed
		EDL08567.1	mixed
		EDL08568.1	mixed
		EDL08569.1	mixed
mRNA	AF327431.1	AAK15699.1
mRNA	AK089276.1	BAC40824.1	NOD
mRNA	AK142397.1	BAE25055.1	C57BL/6J
mRNA	AK143217.1	BAE25312.1	C57BL/6J
mRNA	AK144607.1	BAE25966.1
mRNA	AK155733.1	None	C57BL/6J
mRNA	AK157340.1	BAE34054.1	NOD
mRNA	AK187471.1	None
mRNA	AK206169.1	None
mRNA	BC003901.1	AAH03901.1	FVB/N