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ZNF268 zinc finger protein 268 [ Homo sapiens (human) ]

Gene ID: 10795, updated on 8-May-2016
Official Symbol
ZNF268provided by HGNC
Official Full Name
zinc finger protein 268provided by HGNC
Primary source
HGNC:HGNC:13061
See related
Ensembl:ENSG00000090612 HPRD:05300; MIM:604753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF3
Orthologs
Location:
12q24.33
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (133181409..133207112)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133757995..133783698)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 891 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene zinc finger protein 10 Neighboring gene anomalous homeobox

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: ZNF10

Homology

Clone Names

  • MGC126498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter during mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
release of cytoplasmic sequestered NF-kappaB IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
zinc finger protein 268
Names
zinc finger protein 3
zinc finger protein HZF3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165881.2NP_001159353.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_001159353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AW138703, BC110542
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    Q2TB61
    Related
    ENSP00000228289, OTTHUMP00000237415, ENST00000228289, OTTHUMT00000397192
    Conserved Domains (5) summary
    cd07765
    Location:81120
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:81141
    KRAB; krueppel associated box
    COG5048
    Location:497910
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:710734
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:558578
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001165882.2NP_001159354.1  zinc finger protein 268 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC026786, AC226150, AW138703, BC110542, CN255799
    UniProtKB/TrEMBL
    Q2TB61
    Conserved Domains (5) summary
    cd07765
    Location:237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:258
    KRAB; krueppel associated box
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:627651
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:475495
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001165883.1NP_001159355.1  zinc finger protein 268 isoform d

    See identical proteins and their annotated locations for NP_001159355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, BC058548
    Consensus CDS
    CCDS59240.1
    UniProtKB/Swiss-Prot
    Q14587
    Related
    ENSP00000467781, OTTHUMP00000265185, ENST00000539248, OTTHUMT00000397199
  4. NM_001165884.2NP_001159356.2  zinc finger protein 268 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF432217, AW138703
    Consensus CDS
    CCDS53854.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H1T2
    Related
    ENSP00000438941, OTTHUMP00000237419, ENST00000536899, OTTHUMT00000397198
  5. NM_001165885.1NP_001159357.1  zinc finger protein 268 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (f) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057356
    Consensus CDS
    CCDS53851.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H7L3
    Related
    ENSP00000442446, OTTHUMP00000237417, ENST00000541211, OTTHUMT00000397196
  6. NM_001165886.1NP_001159358.1  zinc finger protein 268 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DQ057357
    Consensus CDS
    CCDS53853.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    F5H670
    Related
    ENSP00000437858, OTTHUMP00000265186, ENST00000542711, OTTHUMT00000452871
  7. NM_001165887.1NP_001159359.1  zinc finger protein 268 isoform h

    See identical proteins and their annotated locations for NP_001159359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon and contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (h) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC026786, AC226150, AF317549, DB079580, DQ057360
    Consensus CDS
    CCDS53852.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    K7EQP6
    Related
    ENSP00000467922, OTTHUMP00000265189, ENST00000592241, OTTHUMT00000452874
    Conserved Domains (2) summary
    cd07765
    Location:1453
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1474
    KRAB; krueppel associated box
  8. NM_003415.2NP_003406.1  zinc finger protein 268 isoform a

    See identical proteins and their annotated locations for NP_003406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC226150, AF317549
    Consensus CDS
    CCDS45012.1
    UniProtKB/Swiss-Prot
    Q14587
    Related
    ENSP00000444412, OTTHUMP00000237414, ENST00000536435, OTTHUMT00000397191
    Conserved Domains (5) summary
    cd07765
    Location:81120
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:81141
    KRAB; krueppel associated box
    COG5048
    Location:497910
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:710734
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:558578
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_152943.2NP_694422.2  zinc finger protein 268 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC226150, AF317549, AF385187
    Consensus CDS
    CCDS59239.1
    UniProtKB/Swiss-Prot
    Q14587
    UniProtKB/TrEMBL
    A0A075B6T9
    Related
    ENSP00000439539, OTTHUMP00000265188, ENST00000541009, OTTHUMT00000452873
    Conserved Domains (2) summary
    cd07765
    Location:81120
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:81141
    KRAB; krueppel associated box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    133181409..133207112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    133577925..133603626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)