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Chd4 chromodomain helicase DNA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 107932, updated on 8-Dec-2014
Official Symbol
Chd4provided by MGI
Official Full Name
chromodomain helicase DNA binding protein 4provided by MGI
Primary source
MGI:MGI:1344380
See related
Ensembl:ENSMUSG00000063870; Vega:OTTMUSG00000023920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA617397; BC005710; Mi-2beta; mKIAA4075; D6Ertd380e; 9530019N15Rik
See Chd4 in Epigenomics, MapViewer
Location:
6 F3; 6 59.28 cM
Exon count:
38
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (125095986..125130591)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene proacrosin binding protein Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene predicted gene, 32616 Neighboring gene microRNA 7045 Neighboring gene NOP2 nucleolar protein Neighboring gene intermediate filament family orphan 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4075, MGC11769

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spindle assembly IEA
Inferred from Electronic Annotation
more info
 
terminal button organization ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
NuRD complex ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
chromodomain-helicase-DNA-binding protein 4
Names
chromodomain-helicase-DNA-binding protein 4
CHD-4
Mi-2 beta
NP_666091.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145979.2NP_666091.1  chromodomain-helicase-DNA-binding protein 4

    See proteins identical to NP_666091.1

    Status: PROVISIONAL

    Source sequence(s)
    AC134529, AC166162
    Consensus CDS
    CCDS20543.1
    UniProtKB/Swiss-Prot
    Q6PDQ2
    Related
    ENSMUSP00000060054, OTTMUSP00000028311, ENSMUST00000056889, OTTMUST00000058439
    Conserved Domains (9) summary
    cd00024
    Location:612667
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10571165
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:444488
    PHD; PHD-finger
    pfam06461
    Location:13711516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17271899
    CHDCT2; CHDCT2 (NUC038) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    125095986..125130591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505280.1XP_006505343.1  

    Conserved Domains (9) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:451495
    PHD; PHD-finger
    pfam06461
    Location:14061551
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17621935
    CHDCT2; CHDCT2 (NUC038) domain
  2. XM_006505281.1XP_006505344.1  

    Conserved Domains (9) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:451495
    PHD; PHD-finger
    pfam06461
    Location:14061551
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17621934
    CHDCT2; CHDCT2 (NUC038) domain
  3. XM_006505285.1XP_006505348.1  

    Conserved Domains (9) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:451495
    PHD; PHD-finger
    pfam06461
    Location:13781523
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17341907
    CHDCT2; CHDCT2 (NUC038) domain
  4. XM_006505286.1XP_006505349.1  

    UniProtKB/TrEMBL
    E9QAS5
    Related
    ENSMUSP00000108009, OTTMUSP00000028313, ENSMUST00000112390, OTTMUST00000058441
    Conserved Domains (9) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:451495
    PHD; PHD-finger
    pfam06461
    Location:13781523
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13021352
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17341906
    CHDCT2; CHDCT2 (NUC038) domain
  5. XM_006505287.1XP_006505350.1  

    Conserved Domains (9) summary
    cd00024
    Location:619674
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:746904
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10641172
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7291025
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:451495
    PHD; PHD-finger
    pfam06461
    Location:13771522
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13011351
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17331906
    CHDCT2; CHDCT2 (NUC038) domain
  6. XM_006505283.1XP_006505346.1  

    Conserved Domains (9) summary
    cd00024
    Location:606661
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:733891
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10511159
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7161012
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:438482
    PHD; PHD-finger
    pfam06461
    Location:13931538
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12891339
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:163217
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17491922
    CHDCT2; CHDCT2 (NUC038) domain
  7. XM_006505282.1XP_006505345.1  

    Conserved Domains (9) summary
    cd00024
    Location:612667
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:739897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10571165
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7221018
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:444488
    PHD; PHD-finger
    pfam06461
    Location:13991544
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12951345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17551928
    CHDCT2; CHDCT2 (NUC038) domain
  8. XM_006505284.1XP_006505347.1  

    Conserved Domains (9) summary
    cd00024
    Location:599654
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:726884
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:10441152
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:7091005
    SNF2_N; SNF2 family N-terminal domain
    pfam00628
    Location:431475
    PHD; PHD-finger
    pfam06461
    Location:13861531
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12821332
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:156210
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17421915
    CHDCT2; CHDCT2 (NUC038) domain

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    126765839..126800494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)