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    NCKAP1 NCK-associated protein 1 [ Homo sapiens ]

    Gene ID: 10787, updated on 11-May-2012
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    Summary

    Official Symbol
    NCKAP1provided by HGNC
    Official Full Name
    NCK-associated protein 1provided by HGNC
    Primary source
    HGNC:7666
    See related
    Ensembl:ENSG00000061676; HPRD:05353; MIM:604891; Vega:OTTHUMG00000132623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEM2; NAP1; NAP125; MGC8981; FLJ11291; KIAA0587
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    Genomic context

    Location :
    2q32
    Sequence :
    Chromosome: 2; NC_000002.11 (183789605..183903229, complement)
    See NCKAP1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 15 Neighboring gene frizzled-related protein Neighboring gene keratin 8 pseudogene 10 Neighboring gene dual specificity phosphatase 19

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt JD, et al. J Cell Biol, 2011 Sep 5. PMID 21875946.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_038464.1 BAB55675.1 ABI1    BIND  PubMed Nap1 interacts with hNap1BP. 
    Q9Y2A7 Q8IZP0 ABI1    HPRD  PubMed  
    Q9Y2A7 C3orf10 protein BRK1    HPRD  PubMed  
    Q9Y2A7 Q96F07 CYFIP2    HPRD  PubMed  
    Q9Y2A7 Q6XZF7 DNMBP    HPRD  PubMed  
    Q9Y2A7 P16333 NCK1    HPRD  PubMed  
    Q9Y2A7 P63000 RAC1    HPRD  PubMed  
    Q9Y2A7 Q92558 WASF1    HPRD  PubMed  
    Q9Y2A7 Q8IV90 WASF2    HPRD  PubMed  
    Q9Y2A7 P61981 YWHAG    HPRD  PubMed  
    BioGRID:116003 BioGRID:115324 ABI1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:116003 BioGRID:116869 DNMBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116003 BioGRID:114094 GAS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116003 BioGRID:111817 RAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:116003 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116003 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116003 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116003 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the NCKAP1 gene: The NCKAP1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    nck-associated protein 1
    Names
    nck-associated protein 1
    NAP 1
    p125Nap1
    membrane-associated protein HEM-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013436.3 → NP_038464.1  nck-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB011159, AI215133, BC015025
      Consensus CDS
      CCDS2287.1
      UniProtKB/Swiss-Prot
      Q9Y2A7
      Related
      ENSP00000355348, OTTHUMP00000163460, ENST00000361354, OTTHUMT00000255867
      Conserved Domains (1) summary
      pfam09735
      Location:8 – 1124
      Blast Score: 4762
      Nckap1; Membrane-associated apoptosis protein

    2. NM_205842.1 → NP_995314.1  nck-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB011159, AI215133, BC015025
      Consensus CDS
      CCDS2288.1
      UniProtKB/Swiss-Prot
      Q9Y2A7
      Related
      ENSP00000354251, OTTHUMP00000163461, ENST00000360982, OTTHUMT00000255868
      Conserved Domains (1) summary
      pfam09735
      Location:8 – 1130
      Blast Score: 4750
      Nckap1; Membrane-associated apoptosis protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      183789605..183903229, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      175647525..175760709, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC064871.6 AAY24196.1
    genomic AC108514.3 AAX93118.1
    genomic CH471058.2 EAX10952.1
      EAX10953.1
      EAX10954.1
      EAX10955.1
      EAX10956.1
      EAX10957.1
    mRNA AB011159.1 BAA25513.2
    mRNA AB014509.1 BAA77295.1
    mRNA AI215133.1 None
    mRNA AK001291.1 BAG50887.1
    mRNA AK292914.1 BAF85603.1
    mRNA BC015025.1 AAH15025.1
    mRNA BT007033.1 AAP35681.1
    other-genetic DQ893545.2 ABM84471.1
    other-genetic DQ893809.2 ABM84735.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2A7.1 GenPept UniProtKB/Swiss-Prot:Q9Y2A7
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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      Links

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