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NCKAP1 NCK-associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10787, updated on 19-Mar-2015
Official Symbol
NCKAP1provided by HGNC
Official Full Name
NCK-associated protein 1provided by HGNC
Primary source
HGNC:HGNC:7666
See related
Ensembl:ENSG00000061676; HPRD:05353; MIM:604891; Vega:OTTHUMG00000132623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEM2; NAP1; NAP125; p125Nap1
Orthologs
See NCKAP1 in MapViewer
Location:
2q32
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (182924851..183038858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183789579..183903586, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 15 Neighboring gene frizzled-related protein Neighboring gene keratin 8 pseudogene 10 Neighboring gene dual specificity phosphatase 19

Replication interactions

Interaction Pubs
Knockdown of NCK-associated protein 1 (NCKAP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC8981, FLJ11291, KIAA0587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
apical protein localization IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
basal protein localization IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
embryonic body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic heart tube development IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of actin cytoskeleton polarity IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell migration IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
notochord morphogenesis IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
zygotic determination of anterior/posterior axis, embryo IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCAR complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nck-associated protein 1
Names
nck-associated protein 1
membrane-associated protein HEM-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013436.4NP_038464.1  nck-associated protein 1 isoform 1

    See proteins identical to NP_038464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AB011159, AC064871, BC015025, CA314471
    Consensus CDS
    CCDS2287.1
    UniProtKB/Swiss-Prot
    Q9Y2A7
    Conserved Domains (1) summary
    pfam09735
    Location:81124
    Nckap1; Membrane-associated apoptosis protein
  2. NM_205842.2NP_995314.1  nck-associated protein 1 isoform 2

    See proteins identical to NP_995314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB011159, AC064871, BC015025, CA314471
    Consensus CDS
    CCDS2288.1
    UniProtKB/Swiss-Prot
    Q9Y2A7
    Related
    ENSP00000354251, OTTHUMP00000163461, ENST00000360982, OTTHUMT00000255868
    Conserved Domains (1) summary
    pfam09735
    Location:81130
    Nckap1; Membrane-associated apoptosis protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    182924851..183038858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712201.2XP_006712264.1  

    See proteins identical to XP_006712264.1

    Conserved Domains (1) summary
    pfam09735
    Location:81122
    Nckap1; Membrane-associated apoptosis protein
  2. XM_006712200.2XP_006712263.1  

    See proteins identical to XP_006712263.1

    Conserved Domains (1) summary
    pfam09735
    Location:81128
    Nckap1; Membrane-associated apoptosis protein

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    183795489..183909486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)