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    NEK6 NIMA (never in mitosis gene a)-related kinase 6 [ Homo sapiens ]

    Gene ID: 10783, updated on 11-May-2012
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    Summary

    Official Symbol
    NEK6provided by HGNC
    Official Full Name
    NIMA (never in mitosis gene a)-related kinase 6provided by HGNC
    Primary source
    HGNC:7749
    Locus tag
    RP11-101K10.6
    See related
    Ensembl:ENSG00000119408; HPRD:05348; MIM:604884; Vega:OTTHUMG00000020650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SID6-1512
    Summary
    The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    9q33.3-q34.11
    Sequence :
    Chromosome: 9; NC_000009.11 (127019885..127114721)
    See NEK6 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505588 Neighboring gene LIM homeobox 2 Neighboring gene uncharacterized LOC100129034 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 7 Neighboring gene G protein-coupled receptor 144

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. Bertran MT, et al. EMBO J, 2011 Jun 3. PMID 21642957.
    3. Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment. Jee HJ, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21539811.
    4. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. Regué L, et al. J Biol Chem, 2011 May 20. PMID 21454704.
    5. Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain. Meirelles GV, et al. BMC Struct Biol, 2011 Feb 14. PMID 21320329.

    See all (36) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
      Title: Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
    2. the first low resolution 3D structure of hNek6 protein in solution
      Title: Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.
    3. These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment.
      Title: Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment.
    4. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
      Title: DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
    5. Findings open new perspectives in the study of hNek6 role in cancer by analyzing its novel interactions in specific pathways in tumor cells, which may provide important implications for drug design and cancer therapy.
      Title: Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
    6. NEK6 expression is downregulated in both replicative and premature senscence of human cnacer cells, and the inhibition of Nek6 activity is important for the onset of cellular senescence.
      Title: Nek6 overexpression antagonizes p53-induced senescence in human cancer cells.
    7. A pivotal role is indicated for Nek6 in tumorigenesis that establishes Nek6 as a potential target for treatment of a variety of human cancers.
      Title: Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target.
    8. NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
      Title: Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common genetic variation and performance on standardized cognitive tests.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9HC98 Q15834 CCDC85B    HPRD  PubMed  
    Q9HC98 P50613 CDK7    HPRD  PubMed  
    Q9HC98 EF hand calcium binding protein 2 NECAB2    HPRD  PubMed  
    Q9HC98 Q8TD19 NEK9    HPRD  PubMed  
    Q9HC98 Q13526 PIN1    HPRD  PubMed  
    Q9HC98 P23443 RPS6KB1    HPRD  PubMed  
    Q9HC98 O00141 SGK1    HPRD  PubMed  
    Q9HC98 Q13485 SMAD4    HPRD  PubMed  
    Q9HC98 Q9HAU4 SMURF2    HPRD  PubMed  
    Q9HC98 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:116000 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:116000 BioGRID:116312 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:114206 DYNLL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:117290 EML2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:129161 EML3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:118169 EML4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:120511 FANCI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:116181 GCN1L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:122828 IPO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:116145 KDELR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:121775 KIAA1967    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:115432 LRPPRC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:110725 MYO1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:120035 NECAB2    BioGRID  PubMed Two-hybrid 
    BioGRID:116000 BioGRID:126636 NEK7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:124876 NEK9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:116000 BioGRID:115041 NUP93    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:120908 PCID2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:119570 PTPLAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:112401 SLC1A5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:114574 SMC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:113867 USP9X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116000 BioGRID:121574 XPO5    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transducer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G2/M transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokinesis TAS
    Traceable Author Statement
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cellular senescence TAS
    Traceable Author Statement
    more info
    		  
    regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    spindle assembly TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek6
    Names
    serine/threonine-protein kinase Nek6
    protein kinase SID6-1512
    nimA-related protein kinase 6
    never in mitosis A-related kinase 6
    putative serine-threonine protein kinase
    NP_001138473.1
    NP_001159639.1
    NP_001159640.1
    NP_001159641.1
    NP_001159642.1
    NP_001159643.1
    NP_055212.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145001.2 → NP_001138473.1  serine/threonine-protein kinase Nek6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 7 encode the same isoform (1).
      Source sequence(s)
      AF087909, AL137846, BC004174, BC012761, CF994196
      Consensus CDS
      CCDS48015.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000362702, OTTHUMP00000022096, ENST00000373600, OTTHUMT00000054017
      Conserved Domains (2) summary
      cd08224
      Location:76 – 341
      Blast Score: 1486
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:79 – 344
      Blast Score: 725
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001166167.1 → NP_001159639.1  serine/threonine-protein kinase Nek6 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF087909, AL137846, BC012761, BM083872
      Consensus CDS
      CCDS55338.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000441469, ENST00000540326
      Conserved Domains (2) summary
      cd08224
      Location:60 – 325
      Blast Score: 1487
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:63 – 328
      Blast Score: 725
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_001166168.1 → NP_001159640.1  serine/threonine-protein kinase Nek6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AF087909, AL137846, BC012761, BP279761
      Consensus CDS
      CCDS6854.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000442636, ENST00000545174
      Conserved Domains (2) summary
      cd08224
      Location:42 – 307
      Blast Score: 1484
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:45 – 310
      Blast Score: 723
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    4. NM_001166169.1 → NP_001159641.1  serine/threonine-protein kinase Nek6 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK294614, AL137846, AL162724, BC012761
      Consensus CDS
      CCDS55339.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000439651, ENST00000539416
      Conserved Domains (2) summary
      cd08224
      Location:67 – 332
      Blast Score: 1493
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:70 – 335
      Blast Score: 729
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    5. NM_001166170.1 → NP_001159642.1  serine/threonine-protein kinase Nek6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AL137846, AL162724, BC012761
      Consensus CDS
      CCDS6854.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000441426, ENST00000546191
      Conserved Domains (2) summary
      cd08224
      Location:42 – 307
      Blast Score: 1484
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:45 – 310
      Blast Score: 723
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    6. NM_001166171.1 → NP_001159643.1  serine/threonine-protein kinase Nek6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.
      Source sequence(s)
      AL137846, AL162724, BC012761, DB350175
      Consensus CDS
      CCDS48015.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000377749, ENST00000394199
      Conserved Domains (2) summary
      cd08224
      Location:76 – 341
      Blast Score: 1486
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:79 – 344
      Blast Score: 725
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    7. NM_014397.5 → NP_055212.2  serine/threonine-protein kinase Nek6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5 and 6 encode the same isoform (2).
      Source sequence(s)
      AF087909, AL137846, BC012761, CF994196
      Consensus CDS
      CCDS6854.1
      UniProtKB/Swiss-Prot
      Q9HC98
      Related
      ENSP00000319734, OTTHUMP00000022095, ENST00000320246, OTTHUMT00000054016
      Conserved Domains (2) summary
      cd08224
      Location:42 – 307
      Blast Score: 1484
      STKc_Nek6_Nek7; Catalytic domain of the Protein Serine/Threonine Kinases, Never In Mitosis gene A-related kinase 6 and 7
      smart00220
      Location:45 – 310
      Blast Score: 723
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      127019885..127114721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      96633275..96727666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137846.24 CAI10875.1
      CAI10876.1
      CAI10877.1
      CAI10878.1
      CAI10879.1
      CAI10880.1
      CAI10881.1
      CAI10882.1
      CAI10883.1
    genomic AL137846.24 CAI10875.1
      CAI10876.1
      CAI10877.1
      CAI10878.1
      CAI10879.1
      CAI10880.1
      CAI10881.1
      CAI10882.1
      CAI10883.1
    genomic AL162724.16 CAH70246.1
      CAH70247.1
      CAH70248.1
      CAH70249.1
      CAH70250.1
      CAH70251.1
      CAH70252.1
      CAH70253.1
      CAH70254.1
    genomic AL162724.16 CAH70246.1
      CAH70247.1
      CAH70248.1
      CAH70249.1
      CAH70250.1
      CAH70251.1
      CAH70252.1
      CAH70253.1
      CAH70254.1
    genomic CH471090.1 EAW87578.1
      EAW87579.1
      EAW87580.1
      EAW87581.1
    mRNA AB026289.1 BAA85045.1
    mRNA AF087909.1 AAG13417.1
    mRNA AJ420460.1 None
    mRNA AK294614.1 BAH11825.1
    mRNA AK313071.1 BAG35899.1
    mRNA BC000101.2 AAH00101.2
    mRNA BC004174.2 AAH04174.2
    mRNA BC004209.2 AAH04209.2
    mRNA BC012761.2 AAH12761.1
    mRNA BM083872.1 None
    mRNA BP219389.1 None
    mRNA BP265230.1 None
    mRNA BP279761.1 None
    mRNA CF994196.1 None
    mRNA CR457091.1 CAG33372.1
    mRNA CR542222.1 CAG47018.1
    mRNA DB350175.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HC98.2 GenPept UniProtKB/Swiss-Prot:Q9HC98
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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