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ZNF266 zinc finger protein 266 [ Homo sapiens (human) ]

Gene ID: 10781, updated on 8-May-2016
Official Symbol
ZNF266provided by HGNC
Official Full Name
zinc finger protein 266provided by HGNC
Primary source
HGNC:HGNC:13059
See related
Ensembl:ENSG00000174652 HPRD:06882; MIM:604751; Vega:OTTHUMG00000179945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF1
Summary
This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Orthologs
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (9412426..9435578, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9523102..9546254, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene zinc finger protein 177 Neighboring gene uncharacterized LOC105372342 Neighboring gene HERV-K_22q11.23 provirus ancestral Gag polyprotein-like Neighboring gene zinc finger protein 560 Neighboring gene uncharacterized LOC105372268

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 266
Names
zinc finger protein 1
zinc finger protein HZF1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271314.1NP_001258243.1  zinc finger protein 266

    See identical proteins and their annotated locations for NP_001258243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011451, AL833503, CN484252, DA735170
    Consensus CDS
    CCDS12213.1
    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000467151, OTTHUMP00000263012, ENST00000588933, OTTHUMT00000449031
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_006631.3NP_006622.2  zinc finger protein 266

    See identical proteins and their annotated locations for NP_006622.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011451, AY376240, CN484252
    Consensus CDS
    CCDS12213.1
    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000467315, OTTHUMP00000263015, ENST00000590306, OTTHUMT00000449034
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    9412426..9435578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722622.2XP_006722685.1  

    See identical proteins and their annotated locations for XP_006722685.1

    Conserved Domains (6) summary
    cd07765
    Location:3976
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006722630.2XP_006722693.1  

    See identical proteins and their annotated locations for XP_006722693.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000468491, OTTHUMP00000263013, ENST00000588221, OTTHUMT00000449032
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_006722626.2XP_006722689.1  

    See identical proteins and their annotated locations for XP_006722689.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011527646.1XP_011525948.1  

    See identical proteins and their annotated locations for XP_011525948.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_006722621.2XP_006722684.1  

    See identical proteins and their annotated locations for XP_006722684.1

    Conserved Domains (6) summary
    cd07765
    Location:3976
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_006722627.2XP_006722690.1  

    See identical proteins and their annotated locations for XP_006722690.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_011527650.1XP_011525952.1  

    See identical proteins and their annotated locations for XP_011525952.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011527649.1XP_011525951.1  

    See identical proteins and their annotated locations for XP_011525951.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_006722620.2XP_006722683.1  

    See identical proteins and their annotated locations for XP_006722683.1

    Conserved Domains (6) summary
    cd07765
    Location:3976
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011527648.1XP_011525950.1  

    See identical proteins and their annotated locations for XP_011525950.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011527647.1XP_011525949.1  

    See identical proteins and their annotated locations for XP_011525949.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_011527645.1XP_011525947.1  

    See identical proteins and their annotated locations for XP_011525947.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. XM_011527644.1XP_011525946.1  

    See identical proteins and their annotated locations for XP_011525946.1

    Conserved Domains (6) summary
    cd07765
    Location:3976
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_006722623.2XP_006722686.1  

    See identical proteins and their annotated locations for XP_006722686.1

    Conserved Domains (6) summary
    cd07765
    Location:3976
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:3995
    KRAB; krueppel associated box
    COG5048
    Location:277616
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:549570
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:199217
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. XM_005259716.2XP_005259773.1  

    See identical proteins and their annotated locations for XP_005259773.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. XM_005259713.2XP_005259770.1  

    See identical proteins and their annotated locations for XP_005259770.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. XM_006722625.2XP_006722688.1  

    See identical proteins and their annotated locations for XP_006722688.1

    UniProtKB/Swiss-Prot
    Q14584
    UniProtKB/TrEMBL
    A0A024R7B6
    Related
    ENSP00000466714, OTTHUMP00000263014, ENST00000592904, OTTHUMT00000449033
    Conserved Domains (4) summary
    COG5048
    Location:210549
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:482503
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132150
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    9522713..9545865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198058.1: Suppressed sequence

    Description
    NM_198058.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.