Format

Send to:

Choose Destination

POP4 POP4 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

Gene ID: 10775, updated on 12-May-2016
Official Symbol
POP4provided by HGNC
Official Full Name
POP4 homolog, ribonuclease P/MRP subunitprovided by HGNC
Primary source
HGNC:HGNC:30081
See related
Ensembl:ENSG00000105171 HPRD:09358; MIM:606114; Vega:OTTHUMG00000182020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPP29
Summary
This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Orthologs
Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (29606263..29617255)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30097170..30108162)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372352 Neighboring gene uncharacterized LOC284395 Neighboring gene V-set and transmembrane domain containing 2B Neighboring gene uncharacterized LOC105372353 Neighboring gene pleckstrin homology and FYVE domain containing 1

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
    tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
mRNA cleavage IEA
Inferred from Electronic Annotation
more info
 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
tRNA 5'-leader removal TAS
Traceable Author Statement
more info
 
tRNA processing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
 
ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ribonuclease P protein subunit p29
Names
hPOP4
NP_006618.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006627.2NP_006618.1  ribonuclease P protein subunit p29

    See identical proteins and their annotated locations for NP_006618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes processing of precursor 4.
    Source sequence(s)
    AC010505, BU727144, Y18863
    Consensus CDS
    CCDS12416.1
    UniProtKB/Swiss-Prot
    O95707
    Related
    ENSP00000465213, OTTHUMP00000268081, ENST00000585603, OTTHUMT00000458710
    Conserved Domains (1) summary
    smart00538
    Location:125215
    POP4; A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins

RNA

  1. NR_027368.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010505, AK303791, BU727144
    Related
    ENST00000221770, OTTHUMT00000458714

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    29606263..29617255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    30098506..30109497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)