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PLK2 polo like kinase 2 [ Homo sapiens (human) ]

Gene ID: 10769, updated on 8-May-2016
Official Symbol
PLK2provided by HGNC
Official Full Name
polo like kinase 2provided by HGNC
Primary source
HGNC:HGNC:19699
See related
Ensembl:ENSG00000145632 HPRD:06118; MIM:607023; Vega:OTTHUMG00000097047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNK; hSNK; hPlk2
Summary
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Orthologs
Location:
5q12.1-q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (58453982..58460139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (57749809..57755966, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378983 Neighboring gene uncharacterized LOC105378984 Neighboring gene uncharacterized LOC105378985 Neighboring gene GRB2-binding adaptor protein, transmembrane

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
signal transducer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
long term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centriole replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
serine/threonine-protein kinase PLK2
Names
PLK-2
polo-like kinase 2
serine/threonine-protein kinase SNK
serum-inducible kinase
NP_001239155.1
NP_006613.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252226.1NP_001239155.1  serine/threonine-protein kinase PLK2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1, however, it maintains the reading frame and encodes a shorter isoform (2) missing a 14 aa protein segment compared to isoform 1.
    Source sequence(s)
    AA954432, AK027851, BC013879, BI559351, N66865
    Consensus CDS
    CCDS75250.1
    UniProtKB/Swiss-Prot
    Q9NYY3
    UniProtKB/TrEMBL
    A0A087WUH9
    Related
    ENSP00000478685, ENST00000617412
    Conserved Domains (4) summary
    smart00220
    Location:68320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:587668
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:489574
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:66320
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2
  2. NM_006622.3NP_006613.2  serine/threonine-protein kinase PLK2 isoform 1

    See identical proteins and their annotated locations for NP_006613.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AA954432, AK027851, BC013879, BI559351, N66865
    Consensus CDS
    CCDS3974.1
    UniProtKB/Swiss-Prot
    Q9NYY3
    UniProtKB/TrEMBL
    A0A024QZV1
    Related
    ENSP00000274289, OTTHUMP00000122549, ENST00000274289, OTTHUMT00000214150
    Conserved Domains (4) summary
    smart00220
    Location:82334
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:601682
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:503588
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:80334
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    58453982..58460139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    57749420..57755577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)