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Nod1 nucleotide-binding oligomerization domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 107607, updated on 28-May-2016
Official Symbol
Nod1provided by MGI
Official Full Name
nucleotide-binding oligomerization domain containing 1provided by MGI
Primary source
MGI:MGI:1341839
See related
Ensembl:ENSMUSG00000038058 Vega:OTTMUSG00000057766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Card4; Nlrc1; C230079P11; F830007N14Rik
Orthologs
Location:
6; 6 B3
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (54923942..54972672, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (54873936..54922606, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene maturin, neural progenitor differentiation regulator homolog (Xenopus) Neighboring gene zinc and ring finger 2 Neighboring gene predicted gene, 38539 Neighboring gene gamma-glutamyl cyclotransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
defense response RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
detection of bacterium ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-8 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic cell antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nucleotide-binding oligomerization domain-containing protein 1
Names
caspase recruitment domain 4
caspase recruitment domain-containing protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171007.1NP_001164478.1  nucleotide-binding oligomerization domain-containing protein 1

    See identical proteins and their annotated locations for NP_001164478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC079183, AI645572, AK137585, AY160222
    Consensus CDS
    CCDS20160.1
    UniProtKB/Swiss-Prot
    Q8BHB0
    UniProtKB/TrEMBL
    Q540J8
    Related
    ENSMUSP00000130487, OTTMUSP00000074069, ENSMUST00000168172, OTTMUST00000141867
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:728941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam05729
    Location:197367
    NACHT; NACHT domain
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    cl14633
    Location:21104
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_172729.3NP_766317.1  nucleotide-binding oligomerization domain-containing protein 1

    See identical proteins and their annotated locations for NP_766317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI645572, AK137585, AY160222
    Consensus CDS
    CCDS20160.1
    UniProtKB/Swiss-Prot
    Q8BHB0
    UniProtKB/TrEMBL
    Q540J8
    Related
    ENSMUSP00000055747, OTTMUSP00000074070, ENSMUST00000060655, OTTMUST00000141868
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:728941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam05729
    Location:197367
    NACHT; NACHT domain
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    cl14633
    Location:21104
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    54923942..54972672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505278.2XP_006505341.1  

    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:728913
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam05729
    Location:197367
    NACHT; NACHT domain
    sd00033
    Location:730754
    LRR_RI; leucine-rich repeat [structural motif]
    cl14633
    Location:21104
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. XM_006505277.2XP_006505340.1  

    See identical proteins and their annotated locations for XP_006505340.1

    UniProtKB/Swiss-Prot
    Q8BHB0
    UniProtKB/TrEMBL
    Q540J8
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:728941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam05729
    Location:197367
    NACHT; NACHT domain
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    cl14633
    Location:21104
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_377400.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    55457493..55496882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001073834.1 Alternate Mm_Celera

    Range
    1305..1653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)