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PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Miniopterus natalensis ]

Gene ID: 107532628, updated on 30-Mar-2024

Summary

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Gene symbol
PIK3CB
Gene description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Gene type
protein coding
RefSeq status
MODEL
Organism
Miniopterus natalensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Miniopteridae; Miniopterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
100 current Mnat.v1 (GCF_001595765.1) Unplaced Scaffold NW_015504407.1 (316918..424823, complement)

NW_015504407.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene centrosomal protein 70 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene 40S ribosomal protein S4, X isoform-like Neighboring gene translationally-controlled tumor protein-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_015504407.1 Unplaced Scaffold Reference Mnat.v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Miniopterus natalensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnat.v1

Genomic

  1. NW_015504407.1 Reference Mnat.v1

    Range
    316918..424823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016207070.1 → XP_016062556.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3

    Conserved Domains (5) summary
    cd08693
    Location:266 → 443
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:123 → 231
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:474 → 644
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:648 → 1009
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam02192
    Location:1 → 60
    PI3K_p85B; PI3-kinase family, p85-binding domain

  2. XM_016207069.1 → XP_016062555.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    Conserved Domains (5) summary
    cd08693
    Location:323 → 500
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:531 → 701
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cl21453
    Location:705 → 1010
    PKc_like; Protein Kinases, catalytic domain

  3. XM_016207068.1 → XP_016062554.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    Conserved Domains (5) summary
    cd08693
    Location:323 → 500
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:531 → 701
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:705 → 1066
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

RNA

  1. XR_001602758.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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