Format

Send to:

Choose Destination

Eprs glutamyl-prolyl-tRNA synthetase [ Mus musculus (house mouse) ]

Gene ID: 107508, updated on 28-May-2016
Official Symbol
Eprsprovided by MGI
Official Full Name
glutamyl-prolyl-tRNA synthetaseprovided by MGI
Primary source
MGI:MGI:97838
See related
Ensembl:ENSMUSG00000026615 Vega:OTTMUSG00000050732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qprs; C79379; 2410081F06Rik; 3010002K18Rik
Orthologs
Location:
1; 1 H4-H6
Exon count:
34
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (185363028..185428355)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (187186974..187252234)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 215 Neighboring gene bisphosphate 3'-nucleotidase 1 Neighboring gene RIKEN cDNA 9630028B13 gene Neighboring gene predicted gene 2061 Neighboring gene solute carrier family 30, member 10

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity, forming aminoacyl-tRNA and related compounds IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
GAIT complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT GAIT complex IDA
Inferred from Direct Assay
more info
PubMed 
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
bifunctional glutamate/proline--tRNA ligase
Names
bifunctional aminoacyl-tRNA synthetase
glutamine-proline-tRNA synthetase
NP_084011.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029735.1NP_084011.1  bifunctional glutamate/proline--tRNA ligase

    See identical proteins and their annotated locations for NP_084011.1

    Status: VALIDATED

    Source sequence(s)
    BC058337, BC094679, BU704580, CB520692, CF537682, CK635189
    Consensus CDS
    CCDS35818.1
    UniProtKB/Swiss-Prot
    Q8CGC7
    Related
    ENSMUSP00000045841, OTTMUSP00000069150, ENSMUST00000046514, OTTMUST00000128583
    Conserved Domains (8) summary
    cd00807
    Location:197506
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    cd10309
    Location:74157
    GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
    PLN02907
    Location:6711
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:10191512
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:10231286
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:12921512
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:753802
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam03950
    Location:504681
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    185363028..185428355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497117.2XP_006497180.1  

    Conserved Domains (8) summary
    cd00807
    Location:197513
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    cd10309
    Location:74157
    GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
    PLN02907
    Location:6718
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:10261519
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:10301293
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:12991519
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:760809
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam03950
    Location:511688
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
  2. XM_006497118.2XP_006497181.1  

    Conserved Domains (6) summary
    PRK08661
    Location:7691262
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:7731036
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:10421262
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:503552
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam03950
    Location:254431
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    cl00015
    Location:1256
    nt_trans; nucleotidyl transferase superfamily
  3. XM_011238908.1XP_011237210.1  

    Conserved Domains (5) summary
    PRK08661
    Location:487980
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:491754
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:760980
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:221270
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam03950
    Location:4149
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    192317193..192381950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001032856.1 Alternate Mm_Celera

    Range
    7719..13591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)