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MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens (human) ]

Gene ID: 10746, updated on 17-Feb-2015
Official Symbol
MAP3K2provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 2provided by HGNC
Primary source
HGNC:HGNC:6854
See related
Ensembl:ENSG00000169967; HPRD:10068; MIM:609487; Vega:OTTHUMG00000153397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEKK2; MEKK2B
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Orthologs
See MAP3K2 in MapViewer
Location:
2q14.3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (127298669..127343229, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128056245..128100805, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene excision repair cross-complementation group 3 Neighboring gene basic proline-rich protein-like Neighboring gene microRNA 4783 Neighboring gene protein C (inactivator of coagulation factors Va and VIIIa)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies MAP3K2, a member of mitogen-activated protein kinase kinase family (serine/threonine protein kinase), is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • MAPK (ERK5) signaling, organism-specific biosystem (from KEGG)
    MAPK (ERK5) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (ERK5) signaling, conserved biosystem (from KEGG)
    MAPK (ERK5) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (JNK) signaling, organism-specific biosystem (from KEGG)
    MAPK (JNK) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (JNK) signaling, conserved biosystem (from KEGG)
    MAPK (JNK) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (p38) signaling, organism-specific biosystem (from KEGG)
    MAPK (p38) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (p38) signaling, conserved biosystem (from KEGG)
    MAPK (p38) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK Cascade, organism-specific biosystem (from WikiPathways)
    MAPK Cascade, organism-specific biosystem
    MAPK Cascade
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
  • Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem (from Pathway Interaction Database)
    Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem
    Trk receptor signaling mediated by the MAPK pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 2
Names
mitogen-activated protein kinase kinase kinase 2
MAP/ERK kinase kinase 2
MAPK/ERK kinase kinase 2
MEK kinase 2
MEKK 2
NP_006600.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006609.4NP_006600.3  mitogen-activated protein kinase kinase kinase 2

    See proteins identical to NP_006600.3

    Status: REVIEWED

    Source sequence(s)
    AC068282, AC110926, BC136293
    Consensus CDS
    CCDS46404.1
    UniProtKB/TrEMBL
    A0A024RAH0
    UniProtKB/Swiss-Prot
    Q9Y2U5
    Related
    ENSP00000387246, OTTHUMP00000203817, ENST00000409947, OTTHUMT00000331014
    Conserved Domains (3) summary
    cd06405
    Location:44122
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:356613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06652
    Location:353616
    STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38 Primary Assembly

    Range
    127298669..127343229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    128060819..128105372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 Alternate HuRef

    Range
    120363448..120407794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)