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lrp6 low density lipoprotein receptor-related protein 6 [ Nothobranchius furzeri (turquoise killifish) ]

Gene ID: 107387741, updated on 14-Mar-2024

Summary

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Gene symbol
lrp6
Gene description
low density lipoprotein receptor-related protein 6
See related
Ensembl:ENSNFUG00015012593
Gene type
protein coding
RefSeq status
MODEL
Organism
Nothobranchius furzeri
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae; Nothobranchius
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_03 current UI_Nfuz_MZM_1.0 (GCF_027789165.1) Unplaced Scaffold NW_026539916.1 (93158271..93207244)
100 previous assembly Nfu_20140520 (GCF_001465895.1) sgr01 NC_029649.1 (96327631..96373788)

NW_026539916.1Genomic Context describing neighboring genes Neighboring gene parathyroid hormone-like hormone a Neighboring gene MANSC domain containing 1 Neighboring gene TANK-binding kinase 1 Neighboring gene G protein-coupled receptor 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels. Petzold A, et al. BMC Genomics, 2013 Mar 16. PMID 23496936, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6
Names
LDL receptor related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027789165.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UI_Nfuz_MZM_1.0 Primary Assembly

Genomic

  1. NW_026539916.1 Reference UI_Nfuz_MZM_1.0 Primary Assembly

    Range
    93158271..93207244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015962897.2 → XP_015818383.1  low-density lipoprotein receptor-related protein 6

    UniProtKB/TrEMBL
    A0A1A7ZZ82, A0A8C6LUQ8
    Related
    ENSNFUP00015026803.1
    Conserved Domains (8) summary
    smart00135
    Location:440 → 483
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1328 → 1362
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:53 → 93
    NHL; NHL repeat [structural motif]
    cl18310
    Location:41 → 157
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1250 → 1287
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:151 → 191
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:594 → 629
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl39070
    Location:1071 → 1112
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
Nucleotide Protein
Heading Accession and Version

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