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bace2 beta-secretase 2 [ Nothobranchius furzeri (turquoise killifish) ]

Gene ID: 107380543, updated on 14-Mar-2024

Summary

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Gene symbol
bace2
Gene description
beta-secretase 2
See related
Ensembl:ENSNFUG00015015535
Gene type
protein coding
RefSeq status
MODEL
Organism
Nothobranchius furzeri
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae; Nothobranchius
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current UI_Nfuz_MZM_1.0 (GCF_027789165.1) Unplaced Scaffold NW_026539919.1 (31133248..31151230, complement)
100 previous assembly Nfu_20140520 (GCF_001465895.1) sgr06 NC_029654.1 (37451224..37469221, complement)

NW_026539919.1Genomic Context describing neighboring genes Neighboring gene nuclear protein, ataxia-telangiectasia locus Neighboring gene ATM serine/threonine kinase Neighboring gene Down syndrome cell adhesion molecule b Neighboring gene uncharacterized LOC129163848 Neighboring gene uncharacterized LOC129163849 Neighboring gene Purkinje cell protein 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels. Petzold A, et al. BMC Genomics, 2013 Mar 16. PMID 23496936, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-secretase 2
Names
beta-site APP-cleaving enzyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027789165.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UI_Nfuz_MZM_1.0 Primary Assembly

Genomic

  1. NW_026539919.1 Reference UI_Nfuz_MZM_1.0 Primary Assembly

    Range
    31133248..31151230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015951841.2 → XP_015807327.1  beta-secretase 2

    UniProtKB/TrEMBL
    A0A1A8VEU6, A0A8C6M907
    Related
    ENSNFUP00015031770.1
    Conserved Domains (1) summary
    cd05473
    Location:82 → 442
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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