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PTPN4 protein tyrosine phosphatase non-receptor type 4 [ Parus major (Great Tit) ]

Gene ID: 107207469, updated on 14-Mar-2024

Summary

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Gene symbol
PTPN4
Gene description
protein tyrosine phosphatase non-receptor type 4
See related
Ensembl:ENSPMJG00000019779
Gene type
protein coding
RefSeq status
MODEL
Organism
Parus major
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Paridae; Parus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
29
Annotation release Status Assembly Chr Location
102 current Parus_major1.1 (GCF_001522545.3) 7 NC_031776.1 (25393021..25507822)
100 previous assembly Parus_major1.0.3 (GCF_001522545.1) 7 NC_029276.1 (31887414..32002214, complement)

Chromosome 7 - NC_031776.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117244709 Neighboring gene transmembrane protein 177 Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene leucine-zipper-like transcriptional regulator 1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Parus major Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Parus_major1.1 Primary Assembly

Genomic

  1. NC_031776.1 Reference Parus_major1.1 Primary Assembly

    Range
    25393021..25507822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015634624.3 → XP_015490110.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    Related
    ENSPMJP00000027143.1, ENSPMJT00000034888.1
    Conserved Domains (8) summary
    smart00194
    Location:660 → 913
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:685 → 912
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain

  2. XM_015634625.2 → XP_015490111.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

    Related
    ENSPMJP00000027145.1, ENSPMJT00000034890.1
    Conserved Domains (8) summary
    smart00194
    Location:670 → 923
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:40 → 232
    B41; Band 4.1 homologues
    cd00047
    Location:695 → 922
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:528 → 615
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:226 → 320
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:132 → 224
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:335 → 375
    FA; FERM adjacent (FA)
    pfam09379
    Location:43 → 107
    FERM_N; FERM N-terminal domain

RNA

  1. XR_001522772.3 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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