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igf1ra insulin-like growth factor 1a receptor [ Cyprinodon variegatus (sheepshead minnow) ]

Gene ID: 107087242, updated on 14-Mar-2024

Summary

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Gene symbol
igf1ra
Gene description
insulin-like growth factor 1a receptor
See related
Ensembl:ENSCVAG00000002588
Gene type
protein coding
RefSeq status
MODEL
Organism
Cyprinodon variegatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae; Cyprinodon
Also known as
igf1r
Orthologs
human zebrafish all
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Genomic context

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See igf1ra in Genome Data Viewer
Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
100 current C_variegatus-1.0 (GCF_000732505.1) Unplaced Scaffold NW_015150630.1 (5169..101413)

NW_015150630.1Genomic Context describing neighboring genes Neighboring gene pyroglutamyl-peptidase 1-like Neighboring gene synemin, intermediate filament protein Neighboring gene myocyte enhancer factor 2aa

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_015150630.1 Unplaced Scaffold Reference C_variegatus-1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor 1 receptor
Names
insulin like growth factor 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cyprinodon variegatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference C_variegatus-1.0 Primary Assembly

Genomic

  1. NW_015150630.1 Reference C_variegatus-1.0 Primary Assembly

    Range
    5169..101413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015378701.1 → XP_015234187.1  insulin-like growth factor 1 receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q2CA13
    Conserved Domains (8) summary
    cd05032
    Location:1027 → 1301
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:499 → 603
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:237 → 283
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd00185
    Location:271 → 307
    TNFRSF; CRD2 [structural motif]
    pfam00757
    Location:183 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:53 → 169
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1034 → 1299
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:219 → 329
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_015378702.1 → XP_015234188.1  insulin-like growth factor 1 receptor isoform X2

    UniProtKB/TrEMBL
    A0A3Q2C9Y3, A0A3Q2CA13
    Related
    ENSCVAP00000001583.1, ENSCVAT00000013181.1
    Conserved Domains (8) summary
    cd05032
    Location:995 → 1269
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:499 → 603
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:237 → 283
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd00185
    Location:271 → 307
    TNFRSF; CRD2 [structural motif]
    pfam00757
    Location:183 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:53 → 169
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1002 → 1267
    Pkinase_Tyr; Protein tyrosine kinase
    cl22855
    Location:219 → 329
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein
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