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DHFR2 dihydrofolate reductase 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 106996159, updated on 13-Mar-2024

Summary

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Gene symbol
DHFR2
Gene description
dihydrofolate reductase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human all
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Genomic context

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Location:
chromosome: 2
Exon count:
2
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (181783299..181789715)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (15093373..15099882, complement)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676458 Neighboring gene NOP2/Sun RNA methyltransferase 3 Neighboring gene U7 small nuclear RNA Neighboring gene ADP ribosylation factor like GTPase 13B Neighboring gene syntaxin 19 Neighboring gene non-histone chromosomal protein HMG-14 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dihydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: dihydrofolate reductase 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    181783299..181789715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015129271.2 → XP_014984757.2  LOW QUALITY PROTEIN: dihydrofolate reductase 2, mitochondrial

    UniProtKB/TrEMBL
    H9EWZ9
    Conserved Domains (1) summary
    cd00209
    Location:5 → 183
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
Nucleotide Protein
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