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PSEN1 presenilin 1 [ Acinonyx jubatus (cheetah) ]

Gene ID: 106974447, updated on 13-Mar-2024

Summary

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Gene symbol
PSEN1
Gene description
presenilin 1
Gene type
protein coding
RefSeq status
MODEL
Organism
Acinonyx jubatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Acinonychinae; Acinonyx
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: B3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_04 current VMU_Ajub_asm_v1.0 (GCF_027475565.1) B3 NC_069386.1 (116071530..116145891)

Chromosome B3 - NC_069386.1Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene RNA binding motif protein 25 Neighboring gene uncharacterized LOC113601375 Neighboring gene uncharacterized LOC113601374 Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene NUMB endocytic adaptor protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_069386.1 Chromosome B3 Reference VMU_Ajub_asm_v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027475565.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference VMU_Ajub_asm_v1.0

Genomic

  1. NC_069386.1 Reference VMU_Ajub_asm_v1.0

    Range
    116071530..116145891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015071685.3 → XP_014927171.2  presenilin-1 isoform X1

    UniProtKB/TrEMBL
    A0A6J1ZWS1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin

  2. XM_015071686.3 → XP_014927172.2  presenilin-1 isoform X2

    UniProtKB/TrEMBL
    A0A6I9ZTV3
    Conserved Domains (1) summary
    pfam01080
    Location:72 → 453
    Presenilin

  3. XM_027066095.2 → XP_026921896.1  presenilin-1 isoform X1

    UniProtKB/TrEMBL
    A0A6J1ZWS1
    Conserved Domains (1) summary
    pfam01080
    Location:76 → 457
    Presenilin
Nucleotide Protein
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