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HIF3A hypoxia inducible factor 3 subunit alpha [ Acinonyx jubatus (cheetah) ]

Gene ID: 106973579, updated on 3-Apr-2024

Summary

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Gene symbol
HIF3A
Gene description
hypoxia inducible factor 3 subunit alpha
Gene type
protein coding
RefSeq status
MODEL
Organism
Acinonyx jubatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Acinonychinae; Acinonyx
Orthologs
human mouse all
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Genomic context

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See HIF3A in Genome Data Viewer
Location:
chromosome: E2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_04 current VMU_Ajub_asm_v1.0 (GCF_027475565.1) E2 NC_069396.1 (50496163..50561375)

Chromosome E2 - NC_069396.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene insulin growth factor-like family member 3 Neighboring gene insulin growth factor-like family member 3 Neighboring gene protein phosphatase 5 catalytic subunit Neighboring gene translation initiation factor IF-2-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_069396.1 Chromosome E2 Reference VMU_Ajub_asm_v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypoxia-inducible factor 3-alpha
Names
hypoxia inducible factor 3 alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027475565.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference VMU_Ajub_asm_v1.0

Genomic

  1. NC_069396.1 Reference VMU_Ajub_asm_v1.0

    Range
    50496163..50561375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_053211380.1 → XP_053067355.1  hypoxia-inducible factor 3-alpha isoform X5

  2. XM_053211381.1 → XP_053067356.1  hypoxia-inducible factor 3-alpha isoform X5

  3. XM_027037858.2 → XP_026893659.1  hypoxia-inducible factor 3-alpha isoform X3

    UniProtKB/TrEMBL
    A0A6J1XMI8, A0A6J1XMJ0
    Conserved Domains (6) summary
    smart00091
    Location:90 → 145
    PAS; PAS domain
    cd00083
    Location:13 → 68
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08447
    Location:251 → 338
    PAS_3; PAS fold
    pfam11413
    Location:480 → 509
    HIF-1; Hypoxia-inducible factor-1
    cl25986
    Location:110 → 192
    PAS_3; PAS fold
    cl26464
    Location:394 → 645
    Atrophin-1; Atrophin-1 family

  4. XM_027037860.2 → XP_026893661.1  hypoxia-inducible factor 3-alpha isoform X6

    UniProtKB/TrEMBL
    A0A6J1XMA6, A0A6J1XMI8
    Conserved Domains (5) summary
    smart00091
    Location:34 → 89
    PAS; PAS domain
    pfam08447
    Location:195 → 282
    PAS_3; PAS fold
    pfam11413
    Location:424 → 453
    HIF-1; Hypoxia-inducible factor-1
    cl25986
    Location:54 → 136
    PAS_3; PAS fold
    cl26464
    Location:338 → 589
    Atrophin-1; Atrophin-1 family

  5. XM_053211379.1 → XP_053067354.1  hypoxia-inducible factor 3-alpha isoform X4

  6. XM_027037859.2 → XP_026893660.2  hypoxia-inducible factor 3-alpha isoform X2

  7. XM_053211377.1 → XP_053067352.1  hypoxia-inducible factor 3-alpha isoform X1

  8. XM_053211382.1 → XP_053067357.1  hypoxia-inducible factor 3-alpha isoform X6

    UniProtKB/TrEMBL
    A0A6J1XMA6

RNA

  1. XR_008293909.1 RNA Sequence

  2. XR_008293910.1 RNA Sequence

Nucleotide Protein
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