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    CCT8 chaperonin containing TCP1, subunit 8 (theta) [ Homo sapiens ]

    Gene ID: 10694, updated on 11-May-2012

    Summary

    Official Symbol
    CCT8provided by HGNC
    Official Full Name
    chaperonin containing TCP1, subunit 8 (theta)provided by HGNC
    Primary source
    HGNC:1623
    See related
    Ensembl:ENSG00000156261; HPRD:10816; Vega:OTTHUMG00000044595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cctq; PRED71; D21S246; C21orf112; KIAA0002

    Genomic context

    Location :
    21q22.11
    Sequence :
    Chromosome: 21; NC_000021.8 (30428647..30446010, complement)
    See CCT8 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene RWD domain containing 2B Neighboring gene ubiquitin specific peptidase 16 Neighboring gene chromosome 21 open reading frame 7 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene long intergenic non-protein coding RNA 189 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 14

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P50990 P60709 ACTB    HPRD  PubMed  
    BioGRID:115933 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:117421 COBRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:123842 CTTNBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:109698 IGBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111512 PPP2R2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111513 PPP2R2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111514 PPP2R2C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115933 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:123249 TRAF3IP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115933 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the CCT8 gene: The CCT8 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    aggresome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit theta
    Names
    T-complex protein 1 subunit theta
    CCT-theta
    TCP-1-theta
    renal carcinoma antigen NY-REN-15
    T-complex protein 1, theta subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006585.2NP_006576.2  T-complex protein 1 subunit theta

      Status: VALIDATED

      Source sequence(s)
      BC072001, BU932439
      Consensus CDS
      CCDS33528.1
      UniProtKB/Swiss-Prot
      P50990
      Related
      ENSP00000286788, OTTHUMP00000096463, ENST00000286788, OTTHUMT00000171822
      Conserved Domains (2) summary
      cd03341
      Location:20527
      Blast Score: 1847
      TCP1_theta; TCP-1 (CTT or eukaryotic type II) chaperonin family, theta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:39527
      Blast Score: 1108
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      30428647..30446010, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      15834853..15852223, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF129075.3 (71991..89354) None
    genomic AL163249.2 CAB90433.1
    genomic CH471079.2 EAX09924.1
      EAX09925.1
      EAX09926.1
    genomic D42052.1 BAA07652.1
    mRNA AK222490.1 BAD96210.1
    mRNA AK293705.1 BAG57138.1
    mRNA AK298801.1 BAG60936.1
    mRNA AK308063.1 None
    mRNA BC005220.1 None
    mRNA BC012584.1 AAH12584.1
    mRNA BC035472.1 None
    mRNA BC072001.1 AAH72001.1
    mRNA BC095470.1 AAH95470.1
    mRNA BU932439.1 None
    mRNA D13627.1 BAA02792.2
    mRNA Z37163.1 CAA85520.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50990.4 GenPept UniProtKB/Swiss-Prot:P50990
    Q53HU0 GenPept UniProtKB/TrEMBL:Q53HU0
    Q7Z759 GenPept UniProtKB/TrEMBL:Q7Z759

      Supplemental Content

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