Display Settings:

Format

Send to:

Choose Destination

    CETN2 centrin, EF-hand protein, 2 [ Homo sapiens ]

    Gene ID: 1069, updated on 11-May-2012

    Summary

    Official Symbol
    CETN2provided by HGNC
    Official Full Name
    centrin, EF-hand protein, 2provided by HGNC
    Primary source
    HGNC:1867
    See related
    Ensembl:ENSG00000147400; HPRD:02051; MIM:300006; Vega:OTTHUMG00000024246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CALT; CEN2
    Summary
    Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    Xq28
    Sequence :
    Chromosome: X; NC_000023.10 (151995871..151999301, complement)
    See CETN2 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene melanoma antigen family A, 3 Neighboring gene melanoma antigen family A, 4 pseudogene Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene zinc finger protein 185 (LIM domain)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed
    Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P41208 O60289 SFI1    HPRD  PubMed  
    P41208 Q01831 XPC    HPRD  PubMed  
    BioGRID:107496 BioGRID:204930 Cetn2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107496 BioGRID:115153 SFI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107496 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107496 BioGRID:123890 USP44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107496 BioGRID:117382 USP49    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107496 BioGRID:113345 XPC    BioGRID  PubMed Co-purification; Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the CETN2 gene: The CETN2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Centrosome maturation, organism-specific biosystem (from REACTOME)
      Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
      Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
    • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
      Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Nucleotide excision repair, organism-specific biosystem (from KEGG)
      Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Nucleotide excision repair, conserved biosystem (from KEGG)
      Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
      Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    XPC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule basal body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    photoreceptor connecting cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrin-2
    Names
    centrin-2
    caltractin (20kD calcium-binding protein)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004344.1NP_004335.1  centrin-2

      Status: REVIEWED

      Source sequence(s)
      X72964
      Consensus CDS
      CCDS14716.1
      UniProtKB/Swiss-Prot
      P41208
      Related
      ENSP00000359300, OTTHUMP00000026058, ENST00000370277, OTTHUMT00000061197
      Conserved Domains (3) summary
      cd00051
      Location:105167
      Blast Score: 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00183
      Location:16172
      Blast Score: 510
      PTZ00183; centrin; Provisional
      cl08302
      Location:3261
      Blast Score: 94
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      151995871..151999301, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AY919675.1 AAW82436.1
    genomic CH471172.2 EAW72900.1
    mRNA AK311940.1 BAG34881.1
    mRNA BC005334.1 AAH05334.1
    mRNA BC013873.2 AAH13873.1
    mRNA BT007256.1 AAP35920.1
    mRNA X72964.1 CAA51467.1
    other-genetic AM393039.1 CAL37917.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41208.1 GenPept UniProtKB/Swiss-Prot:P41208

      Supplemental Content

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...