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MITF melanocyte inducing transcription factor [ Equus asinus (ass) ]

Gene ID: 106827928, updated on 13-Mar-2024

Summary

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Gene symbol
MITF
Gene description
melanocyte inducing transcription factor
See related
Ensembl:ENSEASG00005002172
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus asinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
14
Annotation release Status Assembly Chr Location
101 current ASM1607732v2 (GCF_016077325.2) 21 NC_052197.1 (76629844..76839963)
100 previous assembly ASM130575v1 (GCF_001305755.1) Unplaced Scaffold NW_014637025.1 (1495272..1705697)

Chromosome 21 - NC_052197.1Genomic Context describing neighboring genes Neighboring gene leiomodin 3 Neighboring gene FERM domain containing 4B Neighboring gene uncharacterized LOC106827929 Neighboring gene MyoD family inhibitor domain containing 2 Neighboring gene uncharacterized LOC123279292

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microphthalmia-associated transcription factor
Names
melanogenesis associated transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus asinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1607732v2

Genomic

  1. NC_052197.1 Reference ASM1607732v2

    Range
    76629844..76839963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014836095.2 → XP_014691581.1  microphthalmia-associated transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (3) summary
    cd00083
    Location:253 → 313
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:341 → 454
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 138
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  2. XM_044754340.1 → XP_044610275.1  microphthalmia-associated transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (1) summary
    cd18926
    Location:299 → 402
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  3. XM_014836093.2 → XP_014691579.1  microphthalmia-associated transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Related
    ENSEASP00005002830.2, ENSEAST00005003097.2
    Conserved Domains (3) summary
    cd00083
    Location:309 → 369
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:397 → 510
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  4. XM_014836094.2 → XP_014691580.1  microphthalmia-associated transcription factor isoform X3

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (3) summary
    cd00083
    Location:303 → 363
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:391 → 504
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:56 → 194
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  5. XM_044754341.1 → XP_044610276.1  microphthalmia-associated transcription factor isoform X4

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (1) summary
    cd18926
    Location:293 → 396
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  6. XM_044754347.1 → XP_044610282.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (1) summary
    cd18926
    Location:248 → 351
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  7. XM_044754343.1 → XP_044610278.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (1) summary
    cd18926
    Location:248 → 351
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  8. XM_014836097.2 → XP_014691583.1  microphthalmia-associated transcription factor isoform X6

    UniProtKB/TrEMBL
    A0A9L0KEI8
    Conserved Domains (3) summary
    cd00083
    Location:293 → 353
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:381 → 494
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  9. XM_014836098.2 → XP_014691584.1  microphthalmia-associated transcription factor isoform X7

    UniProtKB/TrEMBL
    A0A9L0IUI7, A0A9L0KEI8
    Related
    ENSEASP00005043773.1, ENSEAST00005063746.1
    Conserved Domains (3) summary
    cd00083
    Location:287 → 347
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:375 → 488
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:40 → 178
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  10. XM_044754346.1 → XP_044610281.1  microphthalmia-associated transcription factor isoform X11

    Conserved Domains (1) summary
    cd18926
    Location:131 → 234
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  11. XM_044754344.1 → XP_044610279.1  microphthalmia-associated transcription factor isoform X9

    UniProtKB/TrEMBL
    A0A9L0JHX8
    Related
    ENSEASP00005052804.1, ENSEAST00005067766.1
    Conserved Domains (1) summary
    cd18926
    Location:193 → 296
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

  12. XM_044754345.1 → XP_044610280.1  microphthalmia-associated transcription factor isoform X10

    Conserved Domains (1) summary
    cd18926
    Location:187 → 290
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
Nucleotide Protein
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