CETN1 centrin, EF-hand protein, 1 [Homo sapiens] - Gene

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Summary

Official Symbol: CETN1provided by HGNC
Official Full Name: centrin, EF-hand protein, 1provided by HGNC
Primary source: HGNC:1866
See related: Ensembl:ENSG00000177143; HPRD:04425; MIM:603187; Vega:OTTHUMG00000131471
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEN1; CETN
Summary: The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 18p11.32

Sequence :: Chromosome: 18; NC_000018.9 (580369..581524)

See CETN1 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis.
Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q12798	P17612	PRKACA		HPRD	PubMed
BioGRID:107495	BioGRID:117382	USP49		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ATP-dependent helicase activity	IEA Inferred from Electronic Annotation more info
G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cellular response to heat	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centriole	IEA Inferred from Electronic Annotation more info
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
photoreceptor connecting cilium	IEA Inferred from Electronic Annotation more info
spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: centrin-1

Names: centrin-1; caltractin; EF-hand protein; calcium binding protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004066.1 → NP_004057.1 centrin-1

Status: REVIEWED

Source sequence(s)

U03270

Consensus CDS

CCDS11820.1

UniProtKB/Swiss-Prot

Q12798

Related

ENSP00000319052, OTTHUMP00000162193, ENST00000327228, OTTHUMT00000254314

Conserved Domains (2) summary

cd00051
Location:105 – 167
Blast Score: 154

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

PTZ00183
Location:22 – 172
Blast Score: 582

PTZ00183; centrin; Provisional

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

580369..581524

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

540396..541552

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001178.4 (8051..9208)	None
genomic	CH471113.2	EAX01727.1
genomic	HC006882.1	CBH19246.1
genomic	HC044503.1	CBH30581.1
mRNA	AK312047.1	BAG34983.1
mRNA	BC029515.1	AAH29515.1
mRNA	U03270.1	AAC27343.1
other-genetic	DQ890970.2	ABM81896.1
other-genetic	DQ894144.2	ABM85070.1