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    DCTN6 dynactin 6 [ Homo sapiens ]

    Gene ID: 10671, updated on 11-May-2012

    Summary

    Official Symbol
    DCTN6provided by HGNC
    Official Full Name
    dynactin 6provided by HGNC
    Primary source
    HGNC:16964
    See related
    Ensembl:ENSG00000104671; HPRD:09907; MIM:612963; Vega:OTTHUMG00000163828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WS3; p27; WS-3
    Summary
    The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    8p12-p11
    Sequence :
    Chromosome: 8; NC_000008.10 (30013813..30041155)
    See DCTN6 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene leptin receptor overlapping transcript-like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene heat shock 70kDa protein 8 pseudogene Neighboring gene transgelin 2 pseudogene 2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:115913 BioGRID:207569 Actr1a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115913 BioGRID:198477 Capza1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115913 BioGRID:199072 Dctn1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115913 BioGRID:213590 Dctn2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115913 BioGRID:207318 Dctn3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115913 BioGRID:113841 NCOA3    BioGRID  PubMed Two-hybrid 
    BioGRID:115913 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dynein binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dynactin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynactin subunit 6
    Names
    dynactin subunit 6
    protein WS-3
    dynactin subunit p27
    novel RGD-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006571.3NP_006562.1  dynactin subunit 6

      Status: REVIEWED

      Source sequence(s)
      BC013175, BI562535, D79389, D84145
      Consensus CDS
      CCDS6076.1
      UniProtKB/Swiss-Prot
      O00399
      Related
      ENSP00000221114, OTTHUMP00000225071, ENST00000221114, OTTHUMT00000375815
      Conserved Domains (1) summary
      cd04646
      Location:10179
      Blast Score: 712
      LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      30013813..30041155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      28558549..28585889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026979.9 (50080..77327) None
    genomic CH471080.2 EAW63466.1
    mRNA AK314128.1 BAG36818.1
    mRNA BC013175.1 AAH13175.1
    mRNA BI562535.1 None
    mRNA CR456851.1 CAG33132.1
    mRNA D79389.1 None
    mRNA D84145.1 BAA19984.1
    other-genetic HQ448326.1 ADQ32806.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00399.1 GenPept UniProtKB/Swiss-Prot:O00399

      Supplemental Content

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