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ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Thamnophis sirtalis ]

Gene ID: 106544185, updated on 13-Mar-2024

Summary

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Gene symbol
ARHGEF7
Gene description
Rho guanine nucleotide exchange factor 7
Gene type
protein coding
RefSeq status
MODEL
Organism
Thamnophis sirtalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
100 current Thamnophis_sirtalis-6.0 (GCF_001077635.1) Unplaced Scaffold NW_013658291.1 (167412..277365)

NW_013658291.1Genomic Context describing neighboring genes Neighboring gene inhibitor of growth family member 1 Neighboring gene ankyrin repeat domain 10 Neighboring gene chromosome-associated kinesin KIF4 pseudogene Neighboring gene integrin subunit beta 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_013658291.1 Unplaced Scaffold Reference Thamnophis_sirtalis-6.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Thamnophis sirtalis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Thamnophis_sirtalis-6.0

Genomic

  1. NW_013658291.1 Reference Thamnophis_sirtalis-6.0

    Range
    167412..277365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014060381.1 → XP_013915856.1  rho guanine nucleotide exchange factor 7 isoform X1

    UniProtKB/TrEMBL
    A0A6I9XPX5
    Conserved Domains (7) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:714 → 800
    betaPIX_CC; betaPIX coiled coil
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21266
    Location:3 → 115
    CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

  2. XM_014060383.1 → XP_013915858.1  rho guanine nucleotide exchange factor 7 isoform X3

    UniProtKB/TrEMBL
    A0A6I9XZ51
    Conserved Domains (8) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam00307
    Location:5 → 107
    CH; Calponin homology (CH) domain
    pfam16523
    Location:714 → 763
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_014060382.1 → XP_013915857.1  rho guanine nucleotide exchange factor 7 isoform X2

    UniProtKB/TrEMBL
    A0A6I9XPD7
    Conserved Domains (7) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam00307
    Location:5 → 107
    CH; Calponin homology (CH) domain
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  4. XM_014060385.1 → XP_013915860.1  rho guanine nucleotide exchange factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A6I9Y7W0
    Conserved Domains (6) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21266
    Location:3 → 115
    CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

  5. XM_014060384.1 → XP_013915859.1  rho guanine nucleotide exchange factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A6I9Y7W0
    Conserved Domains (6) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cd21266
    Location:3 → 115
    CH_betaPIX; calponin homology (CH) domain found in beta-Pak Interactive eXchange factor

  6. XM_014060386.1 → XP_013915861.1  rho guanine nucleotide exchange factor 7 isoform X5

    UniProtKB/TrEMBL
    A0A6I9XPY1
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
Nucleotide Protein
Heading Accession and Version

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