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PDPN podoplanin [ Homo sapiens (human) ]

Gene ID: 10630, updated on 7-Dec-2014
Official Symbol
PDPNprovided by HGNC
Official Full Name
podoplaninprovided by HGNC
Primary source
HGNC:HGNC:29602
Locus tag
CTA-520D8.1
See related
Ensembl:ENSG00000162493; HPRD:16398; MIM:608863; Vega:OTTHUMG00000007912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; T1A-2; AGGRUS; HT1A-1; PA2.26
Summary
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
See PDPN in Epigenomics, MapViewer
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (13583757..13617957)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13910252..13944452)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724825 Neighboring gene PRAME family member 20 Neighboring gene uncharacterized LOC102724856 Neighboring gene leucine rich repeat containing 38 Neighboring gene RNA, 5S ribosomal pseudogene 41 Neighboring gene PR domain containing 2, with ZNF domain

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT folic acid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT water transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
NOT amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular component movement IEA
Inferred from Electronic Annotation
more info
 
NOT folic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphangiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular component movement ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
NOT water transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
podoplanin
Names
podoplanin
PDPN
T1-alpha
hT1alpha-1
hT1alpha-2
PA2.26 antigen
glycoprotein 36
glycoprotein, 36-KD
lung type I cell membrane associated glycoprotein
lung type-I cell membrane-associated glycoprotein (T1A-2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006624.1NP_001006625.1  podoplanin isoform c

    See proteins identical to NP_001006625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
    Consensus CDS
    CCDS44060.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Conserved Domains (1) summary
    pfam05808
    Location:2120
    Podoplanin; Podoplanin
  2. NM_001006625.1NP_001006626.1  podoplanin isoform d

    See proteins identical to NP_001006626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (d) is shorter and has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
    Consensus CDS
    CCDS53270.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Conserved Domains (1) summary
    pfam05808
    Location:2117
    Podoplanin; Podoplanin
  3. NM_006474.4NP_006465.3  podoplanin isoform a

    See proteins identical to NP_006465.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BE887331, BF340649
    Consensus CDS
    CCDS30602.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000479591, ENST00000617617
    Conserved Domains (1) summary
    pfam05808
    Location:77238
    Podoplanin; Podoplanin
  4. NM_198389.2NP_938203.2  podoplanin isoform b

    See proteins identical to NP_938203.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BE887331, BF340649
    Consensus CDS
    CCDS41266.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000365225, OTTHUMP00000009640, ENST00000376057, OTTHUMT00000021784
    Conserved Domains (1) summary
    pfam05808
    Location:77235
    Podoplanin; Podoplanin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    13583757..13617957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710295.1XP_006710358.1  

    See proteins identical to XP_006710358.1

    UniProtKB/Swiss-Prot
    Q86YL7
    Conserved Domains (1) summary
    pfam05808
    Location:2120
    Podoplanin; Podoplanin

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    13708939..13743119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    12427703..12461787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)