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    POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) [ Homo sapiens (human) ]

    Gene ID: 10623, updated on 10-Jun-2013
    Official Symbol
    POLR3Cprovided by HGNC
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide C (62kD)provided by HGNC
    Primary source
    HGNC:30076
    See related
    Ensembl:ENSG00000186141; HPRD:17880; Vega:OTTHUMG00000013753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPC3; RPC62
    Location :
    1q21.1
    Sequence :
    Chromosome: 1; NC_000001.10 (145592605..145610884, complement)
    See POLR3C in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT, 3 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 17 Neighboring gene ring finger protein 115 Neighboring gene CD160 molecule

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BUI4 Q9UKN8 GTF3C4    HPRD  PubMed  
    BioGRID:115868 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115868 BioGRID:109230 GTF3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115868 BioGRID:109231 GTF3C2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115868 BioGRID:114739 GTF3C3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115868 BioGRID:114738 GTF3C4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115868 BioGRID:114737 GTF3C5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115868 BioGRID:122508 NOC4L    BioGRID  PubMed Co-fractionation 
    BioGRID:115868 BioGRID:114909 POLR1C    BioGRID  PubMed Co-fractionation 
    BioGRID:115868 BioGRID:111430 POLR2E    BioGRID  PubMed Co-fractionation 
    BioGRID:115868 BioGRID:116301 POLR3A    BioGRID  PubMed Co-fractionation 
    BioGRID:115868 BioGRID:107129 POLR3D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115868 BioGRID:115866 POLR3F    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:115868 BioGRID:115867 POLR3G    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:115868 BioGRID:128147 POLR3H    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:115868 BioGRID:117587 RSL1D1    BioGRID  PubMed Co-fractionation 
    BioGRID:115868 BioGRID:112771 TBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115868 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115868 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    DNA-directed RNA polymerase III complex TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    DNA-directed RNA polymerase III subunit RPC3
    Names
    DNA-directed RNA polymerase III subunit RPC3
    RNA polymerase III subunit C3
    RNA polymerase III 62 kDa subunit
    DNA-directed III 62 kDa polypeptide
    DNA-directed RNA polymerase III subunit C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006468.6NP_006459.3  DNA-directed RNA polymerase III subunit RPC3

      Status: PROVISIONAL

      Source sequence(s)
      BC002586
      Consensus CDS
      CCDS921.1
      UniProtKB/Swiss-Prot
      Q9BUI4
      Related
      ENSP00000334564, OTTHUMP00000015591, ENST00000334163, OTTHUMT00000038542
      Conserved Domains (2) summary
      pfam05645
      Location:146340
      Blast Score: 440
      RNA_pol_Rpc82; RNA polymerase III subunit RPC82
      pfam08221
      Location:768
      Blast Score: 241
      HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_003871055.2 Reference GRCh37.p10 PATCHES

      Range
      2564734..2583010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      145592605..145610884, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      119556179..119574446, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      152297686..152315962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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