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    RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 [ Homo sapiens ]

    Gene ID: 10616, updated on 11-May-2012

    Summary

    Official Symbol
    RBCK1provided by HGNC
    Official Full Name
    RanBP-type and C3HC4-type zinc finger containing 1provided by HGNC
    Primary source
    HGNC:15864
    Locus tag
    RP5-852M4.4
    See related
    Ensembl:ENSG00000125826; HPRD:16643; MIM:610924; Vega:OTTHUMG00000031634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XAP3; XAP4; HOIL1; RBCK2; RNF54; HOIL-1; ZRANB4; C20orf18; UBCE7IP3
    Summary
    The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    20p13
    Sequence :
    Chromosome: 20; NC_000020.10 (388709..411610)
    See RBCK1 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene neurensin 2 Neighboring gene tribbles homolog 3 (Drosophila) Neighboring gene TBC1 domain family, member 20 Neighboring gene casein kinase 2, alpha 1 polypeptide

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9BYM8 Q92793 CREBBP    HPRD  PubMed  
    Q9BYM8 Q96EP0 RNF31    HPRD  PubMed  
    Q9BYM8 O14544 SOCS6    HPRD  PubMed  
    BioGRID:115862 BioGRID:107047 BACH1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:115862 BioGRID:117121 DDX58    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115862 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115862 BioGRID:109866 IREB2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:115862 BioGRID:110811 NEDD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115862 BioGRID:111565 PRKCB    BioGRID  PubMed Biochemical Activity 
    BioGRID:115862 BioGRID:115862 RBCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:115862 BioGRID:120389 RNF31    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115862 BioGRID:207682 Socs6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115862 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115862 BioGRID:113037 TRAF1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:115862 BioGRID:113500 TRIM25    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:115862 BioGRID:113165 UBA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115862 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:115862 BioGRID:113171 UBE2D3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115862 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:113174 UBE2G1    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:109340 UBE2K    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:113180 UBE2L3    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:114672 UBE2L6    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:118150 UBE2S    BioGRID  PubMed Two-hybrid 
    BioGRID:115862 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
     
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    LUBAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ranBP-type and C3HC4-type zinc finger-containing protein 1
    Names
    ranBP-type and C3HC4-type zinc finger-containing protein 1
    RING finger protein 54
    HBV associated factor 4
    HBV-associated factor 4
    RBCC protein interacting with PKC1
    heme-oxidized IRP2 ubiquitin ligase 1
    hepatitis B virus X-associated protein 4
    ubiquitin conjugating enzyme 7 interacting protein 3
    ubiquitin-conjugating enzyme 7-interacting protein 3
    NP_006453.1
    NP_112506.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006462.4NP_006453.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks exon 2, which contains a translation start codon used by variant 2. Instead, it uses an in-frame start codon in exon 1, resulting in isoform 1 that has a distinct N-terminus compared to that of isoform 2.
      Source sequence(s)
      AB107766, BC014116, BC015219
      Consensus CDS
      CCDS12998.1
      UniProtKB/Swiss-Prot
      Q9BYM8
      Related
      ENSP00000254960, OTTHUMP00000029921, ENST00000353660, OTTHUMT00000077460
      Conserved Domains (4) summary
      cd01799
      Location:1589
      Blast Score: 383
      Hoil1_N; Ubiquitin-like domain of HOIL1
      pfam01485
      Location:309369
      Blast Score: 80
      IBR; IBR domain
      cl02656
      Location:155175
      Blast Score: 84
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl15348
      Location:239283
      Blast Score: 78
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_031229.2NP_112506.2  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      BC014116, BC015219
      Consensus CDS
      CCDS13000.2
      UniProtKB/Swiss-Prot
      Q9BYM8
      Related
      ENSP00000348632, OTTHUMP00000029922, ENST00000356286, OTTHUMT00000077461
      Conserved Domains (4) summary
      cd01799
      Location:57131
      Blast Score: 382
      Hoil1_N; Ubiquitin-like domain of HOIL1
      pfam01485
      Location:351411
      Blast Score: 82
      IBR; IBR domain
      cl02656
      Location:197217
      Blast Score: 85
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl15348
      Location:281325
      Blast Score: 80
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      388709..411610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      340142..362963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031227.1: Suppressed sequence

      Description
      NM_031227.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_031228.1: Suppressed sequence

      Description
      NM_031228.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121747.41 CAC17516.1
      CAC28312.2
      CAI23017.2
      CAI23018.2
      CAO03633.1
    genomic AL121747.41 CAC17516.1
      CAC28312.2
      CAI23017.2
      CAI23018.2
      CAO03633.1
    genomic CH471133.3 EAX10673.1
      EAX10675.1
    mRNA AB107766.1 BAC75409.1
    mRNA AK297524.1 BAG59927.1
    mRNA AK309414.1 None
    mRNA BC000983.2 None
    mRNA BC014116.2 None
    mRNA BC015219.2 AAH15219.2
    mRNA BC016301.2 None
    mRNA U67322.1 AAD00162.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JWR1 GenPept UniProtKB/TrEMBL:Q5JWR1
    Q9BYM8.2 GenPept UniProtKB/Swiss-Prot:Q9BYM8

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