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HEXIM1 hexamethylene bis-acetamide inducible 1 [ Homo sapiens (human) ]

Gene ID: 10614, updated on 8-Oct-2014
Official Symbol
HEXIM1provided by HGNC
Official Full Name
hexamethylene bis-acetamide inducible 1provided by HGNC
Primary source
HGNC:HGNC:24953
See related
HPRD:09544; MIM:607328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLP1; EDG1; HIS1; MAQ1
Summary
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
See HEXIM1 in Epigenomics, MapViewer
Location:
17q21.31
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (45147317..45152101)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43224684..43229468)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 6784 Neighboring gene phospholipase C, delta 3 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene hexamethylene bis-acetamide inducible 2 Neighboring gene uncharacterized LOC339192 Neighboring gene formin-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat displaces HEXIM1 from Cyclin T1 in the context of the native 7SK snRNP by interacting with the Cyclin T1-binding domain (amino acid 255-359) of HEXIM1 PubMed
tat CDK11 depletion reduces protein expression of CDK9 and HEXIM1 and Tat transactivation of HIV-1 provirus PubMed
tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat-mediated release of P-TEFb from the 7SK sn RNP results in a conformational change in 7SK RNA and release of HEXIM1 from the complex PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat competes with HEXIM1 for binding to 7SK RNA and inhibits the formation of the P-TEFb-HEXIM1-7SK complex. Tat binds to nucleotides 10-48 of 7SK RNA PubMed
tat HIV-1 Tat directly interacts with human 7SK snRNA in living cells. The 5' hairpin of human 7SK snRNA carries a conserved Tat-binding element and two HEXIM1-binding sites. Tat competes with HEXIM1 for 7SK snRNA binding PubMed
tat HIV-1 Tat transactivation is effectively inhibited by co-expression of HEXIM1 or its paralog HEXIM2; HEXIM1 expression specifically represses transcription mediated by the direct activation of P-TEFb through Tat recruitment of CycT1 PubMed
tat MAQ1 complexes with 7SK RNA and cyclin T1 and competes with the binding of Tat to cyclin T1, suggesting the TAR RNA/Tat lentivirus system has evolved to subvert the cellular 7SK RNA/MAQ1 system PubMed
tat HIV-1 Tat competes with Hexim1 (residues 255-359) for cyclin T1 binding, thus releasing P-TEFb from the inactive complex to stimulate the transcription of HIV-1 gene expression PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein HEXIM1
Names
protein HEXIM1
HMBA-inducible
menage a quatre 1
cardiac lineage protein 1
menage a quatre protein 1
estrogen down-regulated gene 1 protein
hexamthylene bis-acetamide inducible 1
hexamethylene bisacetamide-inducible protein
hexamethylene bis-acetamide-inducible protein 1
hexamethylene-bis-acetamide-inducible transcript 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006460.2NP_006451.1  protein HEXIM1

    See proteins identical to NP_006451.1

    Status: REVIEWED

    Source sequence(s)
    AB021179, AC142472, AI092623, AL562001, AW881781, BC006460, BQ777682, BX111838, CA448958, CA946973, CV810471, DB539383
    Consensus CDS
    CCDS11495.1
    UniProtKB/Swiss-Prot
    O94992
    Conserved Domains (1) summary
    pfam15313
    Location:164302
    HEXIM; Hexamethylene bis-acetamide-inducible protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    45147317..45152101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    38987505..38992292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    43460225..43465014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)