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MXD4 MAX dimerization protein 4 [ Homo sapiens (human) ]

Gene ID: 10608, updated on 8-May-2016
Official Symbol
MXD4provided by HGNC
Official Full Name
MAX dimerization protein 4provided by HGNC
Primary source
HGNC:HGNC:13906
See related
Ensembl:ENSG00000123933 HPRD:10103; Vega:OTTHUMG00000090243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAD4; MST149; MSTP149; bHLHc12
Summary
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4p16.3
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (2247432..2262143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2249160..2263739, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene HBS1 like translational GTPase pseudogene Neighboring gene polymerase (DNA) nu Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 5 Neighboring gene uncharacterized LOC102723755 Neighboring gene HAUS augmin like complex subunit 3 Neighboring gene microRNA 4800 Neighboring gene zinc finger FYVE-type containing 28 Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene uncharacterized LOC105374352

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
max dimerization protein 4
Names
Mad4 homolog
class C basic helix-loop-helix protein 12
max dimerizer 4
max-associated protein 4
max-interacting transcriptional repressor MAD4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006454.2NP_006445.1  max dimerization protein 4

    See identical proteins and their annotated locations for NP_006445.1

    Status: REVIEWED

    Source sequence(s)
    AF082740
    Consensus CDS
    CCDS3361.1
    UniProtKB/Swiss-Prot
    Q14582
    Related
    ENSP00000337889, OTTHUMP00000115253, ENST00000337190, OTTHUMT00000206519
    Conserved Domains (1) summary
    cd00083
    Location:53108
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    2247432..2262143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513390.1XP_011511692.1  

    See identical proteins and their annotated locations for XP_011511692.1

    Conserved Domains (1) summary
    cd00083
    Location:76118
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_011513389.1XP_011511691.1  

    See identical proteins and their annotated locations for XP_011511691.1

    Conserved Domains (1) summary
    cd00083
    Location:76118
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. XM_011513388.1XP_011511690.1  

    Conserved Domains (1) summary
    cd00083
    Location:120162
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RNA

  1. XR_427467.1 RNA Sequence

  2. XR_924911.1 RNA Sequence

  3. XR_924912.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    2247665..2262244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)