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Pola1 DNA polymerase alpha 1, catalytic subunit [ Dipodomys ordii (Ord's kangaroo rat) ]

Gene ID: 105993263, updated on 13-Mar-2024

Summary

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Gene symbol
Pola1
Gene description
DNA polymerase alpha 1, catalytic subunit
See related
Ensembl:ENSDORG00000010871
Gene type
protein coding
RefSeq status
MODEL
Organism
Dipodomys ordii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae; Dipodomyinae; Dipodomys
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
37
Annotation release Status Assembly Chr Location
100 current Dord_2.0 (GCF_000151885.1) Unplaced Scaffold NW_012267310.1 (4643103..4955603)

NW_012267310.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase 3 Neighboring gene phosphate cytidylyltransferase 1B, choline Neighboring gene aristaless related homeobox Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012267310.1 Unplaced Scaffold Reference Dord_2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyrimidine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lagging strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leading strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase alpha catalytic subunit
Names
polymerase (DNA directed), alpha 1, catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Dipodomys ordii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Dord_2.0

Genomic

  1. NW_012267310.1 Reference Dord_2.0

    Range
    4643103..4955603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013026467.1 → XP_012881921.1  DNA polymerase alpha catalytic subunit

    UniProtKB/TrEMBL
    A0A1S3FZD7
    Related
    ENSDORP00000010219.2, ENSDORT00000010873.2
    Conserved Domains (5) summary
    cd05776
    Location:541 → 773
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:836 → 1245
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:57 → 1229
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:1269 → 1468
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:42 → 102
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
Nucleotide Protein
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