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Espl1 extra spindle pole bodies 1, separase [ Mus musculus (house mouse) ]

Gene ID: 105988, updated on 28-May-2016
Official Symbol
Espl1provided by MGI
Official Full Name
extra spindle pole bodies 1, separaseprovided by MGI
Primary source
MGI:MGI:2146156
See related
Ensembl:ENSMUSG00000058290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSE; Cerp; ESP1; PRCE; AL024103; AU045071
Orthologs
Location:
15; 15 F3
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (102296253..102324357)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (102126724..102154787)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9918 Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene prefoldin 5 Neighboring gene melanocyte proliferating gene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IGI
Inferred from Genetic Interaction
more info
PubMed 
homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
 
meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
separin
Names
Cut1/ESP1 related protein
caspase-like protein ESPL1
extra spindle pole bodies 1
extra spindle poles-like 1 protein
separase
NP_001014976.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014976.2NP_001014976.1  separin

    See identical proteins and their annotated locations for NP_001014976.1

    Status: VALIDATED

    Source sequence(s)
    AC163291
    Consensus CDS
    CCDS27878.1
    UniProtKB/Swiss-Prot
    P60330
    Related
    ENSMUSP00000064465, ENSMUST00000064924
    Conserved Domains (1) summary
    pfam03568
    Location:17122065
    Peptidase_C50; Peptidase family C50

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    102296253..102324357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245396.1XP_011243698.1  

    See identical proteins and their annotated locations for XP_011243698.1

    UniProtKB/Swiss-Prot
    P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17122065
    Peptidase_C50; Peptidase family C50
  2. XM_006520258.2XP_006520321.1  

    See identical proteins and their annotated locations for XP_006520321.1

    UniProtKB/Swiss-Prot
    P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17122065
    Peptidase_C50; Peptidase family C50
  3. XM_006520257.2XP_006520320.1  

    See identical proteins and their annotated locations for XP_006520320.1

    UniProtKB/Swiss-Prot
    P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17122065
    Peptidase_C50; Peptidase family C50
  4. XM_006520259.2XP_006520322.1  

    See identical proteins and their annotated locations for XP_006520322.1

    UniProtKB/Swiss-Prot
    P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17122065
    Peptidase_C50; Peptidase family C50
  5. XM_011245397.1XP_011243699.1  

    Conserved Domains (1) summary
    pfam03568
    Location:11731526
    Peptidase_C50; Peptidase family C50

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    104453712..104481413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)