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mthfr methylenetetrahydrofolate reductase (NAD(P)H) [ Fundulus heteroclitus (mummichog) ]

Gene ID: 105921973, updated on 13-Mar-2024

Summary

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Gene symbol
mthfr
Gene description
methylenetetrahydrofolate reductase (NAD(P)H)
See related
Ensembl:ENSFHEG00000001200
Gene type
protein coding
RefSeq status
MODEL
Organism
Fundulus heteroclitus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae; Fundulus
Orthologs
human zebrafish all
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Genomic context

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See mthfr in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
102 current MU-UCD_Fhet_4.1 (GCF_011125445.2) Unplaced Scaffold NW_023397011.1 (238652..332986)
101 previous assembly Fundulus_heteroclitus-3.0.2 (GCF_000826765.1) Unplaced Scaffold NW_012225301.1 (18662..67696, complement)

NW_023397011.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118561193 Neighboring gene uncharacterized LOC118561194 Neighboring gene coiled-coil domain containing 22 Neighboring gene renin binding protein Neighboring gene ligand dependent nuclear receptor interacting factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Fundulus heteroclitus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MU-UCD_Fhet_4.1 Primary Assembly

Genomic

  1. NW_023397011.1 Reference MU-UCD_Fhet_4.1 Primary Assembly

    Range
    238652..332986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036133128.1 → XP_035989021.1  methylenetetrahydrofolate reductase isoform X1

    UniProtKB/TrEMBL
    A0A3Q2NNI3
    Conserved Domains (1) summary
    cl00246
    Location:64 → 630
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  2. XM_036133129.1 → XP_035989022.1  methylenetetrahydrofolate reductase isoform X2

    UniProtKB/TrEMBL
    A0A3Q2NNI3
    Conserved Domains (1) summary
    cl00246
    Location:64 → 593
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  3. XM_036133130.1 → XP_035989023.1  methylenetetrahydrofolate reductase isoform X3

    UniProtKB/TrEMBL
    A0A3Q2NNI3
    Conserved Domains (1) summary
    cl00246
    Location:1 → 544
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein
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