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    CENPA centromere protein A [ Homo sapiens ]

    Gene ID: 1058, updated on 11-May-2012

    Summary

    Official Symbol
    CENPAprovided by HGNC
    Official Full Name
    centromere protein Aprovided by HGNC
    Primary source
    HGNC:1851
    See related
    Ensembl:ENSG00000115163; HPRD:00313; MIM:117139; Vega:OTTHUMG00000097073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CenH3; CENP-A
    Summary
    Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    2p24-p21
    Sequence :
    Chromosome: 2; NC_000002.11 (27008882..27017457)
    See CENPA in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 3 Neighboring gene chromosome 2 open reading frame 18 Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 2 Neighboring gene dihydropyrimidinase-like 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001800.1 NP_005210.2 DIAPH1    BIND  PubMed mDia1 interacts with CENP-A. This interaction was modelled on a demonstrated interaction between mDia1 from mouse and CENP-A from human. 
    NP_001800.1 NP_009293.1 DIAPH2    BIND  PubMed mDia3 interacts with CENP-A. 
    P49450 Q96GD4 AURKB    HPRD  PubMed  
    P49450 O60610 DIAPH1    HPRD  PubMed  
    P49450 O60879 DIAPH2    HPRD  PubMed  
    P49450 Histone 1 H3c HIST1H3C    HPRD  PubMed  
    P49450 Histone 1 H4f HIST1H4F    HPRD  PubMed  
    P49450 P09874 PARP1    HPRD  PubMed  
    P49450 Q9UGN5 PARP2    HPRD  PubMed  
    BioGRID:107487 BioGRID:106575 ACTB    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114646 AURKB    BioGRID  PubMed Biochemical Activity 
    BioGRID:107487 BioGRID:112671 AURKC    BioGRID  PubMed Biochemical Activity 
    BioGRID:107487 BioGRID:107116 BMI1    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:116463 CBX3    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:121487 CBX8    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:107487 CENPA    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:107488 CENPB    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:122355 CENPH    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:108769 CENPI    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:122063 CENPK    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:122488 CENPM    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:120942 CENPN    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:122589 CENPO    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:123143 CENPT    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:108009 DDB1    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:108289 EIF4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:108399 FBL    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114927 H2AFY    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:109272 H3F3A    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:109261 HIST1H1C    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:113931 HIST1H2AB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:109267 HIST1H2AD    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:109271 HIST1H2BB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:113948 HIST1H3C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107487 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107487 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:120635 HJURP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:107487 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:135921 HPC3    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:109544 HSPA8    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:117452 KIAA1429    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114873 KIF23    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:129867 LOC284412    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:122805 MLF1IP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107487 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107487 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107487 BioGRID:120353 PHIP    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:111947 RING1    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:111972 RNF2    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:119724 RSF1    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:122898 SHCBP1    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114045 SMARCA5    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:119626 SRRT    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:114957 WTAP    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107487 BioGRID:116719 ZC3H13    BioGRID  PubMed Co-purification 
    BioGRID:107487 BioGRID:123322 ZFP91    BioGRID  PubMed Co-purification 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    CenH3-containing nucleosome assembly at centromere TAS
    Traceable Author Statement
    more info
     
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
     
    nucleosome assembly TAS
    Traceable Author Statement
    more info
     
    protein localization to chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome inner kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histone H3-like centromeric protein A
    Names
    histone H3-like centromeric protein A
    centromere autoantigen A
    centromere protein A, 17kDa
    centromere-specific histone

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042426.1NP_001035891.1  histone H3-like centromeric protein A isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AC011740, BC000881
      Consensus CDS
      CCDS42662.1
      UniProtKB/Swiss-Prot
      P49450
      Related
      ENSP00000233505, OTTHUMP00000214068, ENST00000233505, OTTHUMT00000353282
      Conserved Domains (1) summary
      cl00074
      Location:38111
      Blast Score: 274
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
    2. NM_001809.3NP_001800.1  histone H3-like centromeric protein A isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC011740, U14518
      Consensus CDS
      CCDS1729.1
      UniProtKB/Swiss-Prot
      P49450
      Related
      ENSP00000336868, OTTHUMP00000122589, ENST00000335756, OTTHUMT00000214190
      Conserved Domains (1) summary
      cl00074
      Location:38137
      Blast Score: 349
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      27008882..27017457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      26750612..26759190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011740.7 AAX93267.1
    genomic CH471053.2 EAX00669.1
      EAX00670.1
      EAX00671.1
      EAX00672.1
    genomic U82609.1 AAB47505.1
    mRNA BC000881.1 AAH00881.1
    mRNA BC002703.2 AAH02703.1
    mRNA BC011013.1 None
    mRNA BT007246.1 AAP35910.1
    mRNA U14518.1 AAA57416.1
    other-genetic HQ448742.1 ADQ33220.1
    other-genetic JF432571.1 ADZ15788.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49450.1 GenPept UniProtKB/Swiss-Prot:P49450

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