TACC2 transforming, acidic coiled-coil containing protein 2 [Homo sapiens] - Gene

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Summary

Official Symbol: TACC2provided by HGNC
Official Full Name: transforming, acidic coiled-coil containing protein 2provided by HGNC
Primary source: HGNC:11523
Locus tag: RP11-296H2.1
See related: Ensembl:ENSG00000138162; HPRD:05600; MIM:605302; Vega:OTTHUMG00000019181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AZU-1; ECTACC
Summary: Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 10q26

Sequence :: Chromosome: 10; NC_000010.10 (123748689..124014057)

See TACC2 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TACC2 may mediate an oncogenic effect on breast cancer cells.
Title: Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Simian virus 40 large T antigen interacting with TACC2 is involved in stabilizing microtubules in mitosis.
Title: Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.
Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
GCN5L2 is a TACC2-binding protein.
Title: The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
Centrosomal TACC2 is required for mitotic spindle maintenance.
Title: TTK kinase is essential for the centrosomal localization of TACC2.
Defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors.
Title: Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2.

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_996743.1	NP_004371.1	CREBBP	BIND	PubMed	TACC2 interacts with CBP.
NP_996743.1	NP_001420.2	EP300	BIND	PubMed	TACC2 interacts with p300.
NP_996743.1	NP_066564.1	KAT2A	BIND	PubMed	TACC2 interacts with hGCN5L2.
NP_996743.1	NP_003875.3	KAT2B	BIND	PubMed	TACC2 interacts with pCAF.
O95359	Q9UQB9	AURKC	HPRD	PubMed
O95359	Q92793	CREBBP	HPRD	PubMed
O95359	Q09472	EP300	HPRD	PubMed
O95359	Q9P0W2	HMG20B	HPRD	PubMed
O95359	Q92830	KAT2A	HPRD	PubMed
O95359	Q92831	KAT2B	HPRD	PubMed
O95359	P28702	RXRB	HPRD	PubMed
O95359	Q12824	SMARCB1	HPRD	PubMed
O95359	O95619	YEATS4	HPRD	PubMed
BioGRID:115830	BioGRID:115137	CKAP5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115830	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115830	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115830	BioGRID:115642	HMG20B	BioGRID	PubMed	Two-hybrid
BioGRID:115830	BioGRID:230424	Haus1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115830	BioGRID:230105	Haus4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115830	BioGRID:108918	KAT2A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115830	BioGRID:114375	KAT2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115830	BioGRID:112482	SMARCB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115830	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:115830	BioGRID:113761	YEATS4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
nuclear hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
astral microtubule organization	IEA Inferred from Electronic Annotation more info
cell proliferation	IEA Inferred from Electronic Annotation more info
cerebral cortex development	IEA Inferred from Electronic Annotation more info
interkinetic nuclear migration	IEA Inferred from Electronic Annotation more info
microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
neurogenesis	IEA Inferred from Electronic Annotation more info
regulation of microtubule-based process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
microtubule organizing center	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: transforming acidic coiled-coil-containing protein 2

Names: transforming acidic coiled-coil-containing protein 2; anti zuai-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029948.1 RefSeqGene

Range

5001..270369

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006997.2 → NP_008928.1 transforming acidic coiled-coil-containing protein 2 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a different segment for its 5' UTR and coding region when compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AF095791, BC039311

Consensus CDS

CCDS7627.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000260733, OTTHUMP00000020645, ENST00000260733, OTTHUMT00000050774

Conserved Domains (1) summary

pfam05010
Location:820 – 1025
Blast Score: 794

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_206860.1 → NP_996742.1 transforming acidic coiled-coil-containing protein 2 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses a different segment for its 5' UTR and coding region, and also lacks an internal coding region segment when it is compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus when compared to isoform a.

Source sequence(s)

BC000999, BC039311

Consensus CDS

CCDS7628.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000353763, OTTHUMP00000217070, ENST00000360561, OTTHUMT00000050762

Conserved Domains (1) summary

pfam05010
Location:790 – 995
Blast Score: 801

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_206861.1 → NP_996743.1 transforming acidic coiled-coil-containing protein 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks three internal in-frame coding region segments when compared to variant 1. The resulting protein (isoform b) is shorter when compared to isoform a. Isoform b has also been called the 'short' isoform

Source sequence(s)

AF528098, BC000999, BC010219

Consensus CDS

CCDS7625.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000425062, OTTHUMP00000217061, ENST00000513429, OTTHUMT00000358353

Conserved Domains (1) summary

pfam05010
Location:888 – 1093
Blast Score: 797

TACC; Transforming acidic coiled-coil-containing protein (TACC)
NM_206862.2 → NP_996744.2 transforming acidic coiled-coil-containing protein 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Isoform a has also been called the 'long' isoform.

Source sequence(s)

AC063960, AF528099, AL833304, BC000999, BC010219

Consensus CDS

CCDS7626.1

UniProtKB/Swiss-Prot

O95359

Related

ENSP00000358001, OTTHUMP00000035135, ENST00000369005, OTTHUMT00000090004

Conserved Domains (2) summary

pfam05010
Location:2742 – 2947
Blast Score: 869

TACC; Transforming acidic coiled-coil-containing protein (TACC)

cl07975
Location:2784 – 2946
Blast Score: 105

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

123748689..124014057

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

117379396..117644911

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC063960.10	None
genomic	AL135793.13	CAI95126.1
		CAI95127.1
		CAI95128.1
		CAI95129.1
		CAI95130.1
		CAI95131.1
		CAI95132.1
		CAI95134.1
genomic	AL135793.13	CAI95126.1
		CAI95127.1
		CAI95128.1
		CAI95129.1
		CAI95130.1
		CAI95131.1
		CAI95132.1
		CAI95134.1
genomic	AL731566.7 (98129..123921)	None
genomic	CH471066.2	EAW49325.1
mRNA	AF095791.2	AAC64968.2
mRNA	AF176646.1	AAF63433.1
mRNA	AF220152.2	AAF29537.2
mRNA	AF528098.1	AAO62629.1
mRNA	AF528099.1	AAO62630.1
mRNA	AK027066.1	None
mRNA	AK056743.1	None
mRNA	AK075097.1	None
mRNA	AK094848.1	None
mRNA	AK095371.1	None
mRNA	AK295631.1	BAH12132.1
mRNA	AL713712.1	CAD28509.1
mRNA	AL833304.1	None
mRNA	BC000999.2	AAH00999.1
mRNA	BC010219.1	None
mRNA	BC015736.1	None
mRNA	BC029124.1	None
mRNA	BC031036.1	None
mRNA	BC039311.1	AAH39311.1
mRNA	BC141837.1	None
mRNA	BC142673.1	None
mRNA	BC144599.1	AAI44600.1
mRNA	BC144600.1	AAI44601.1
mRNA	BC150627.1	AAI50628.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O95359.3	GenPept	UniProtKB/Swiss-Prot:O95359
Q4VXL2	GenPept	UniProtKB/TrEMBL:Q4VXL2
Q4VXL4	GenPept	UniProtKB/TrEMBL:Q4VXL4
Q4VXL5	GenPept	UniProtKB/TrEMBL:Q4VXL5
Q4VXL8	GenPept	UniProtKB/TrEMBL:Q4VXL8