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Ano6 anoctamin 6 [ Mus musculus (house mouse) ]

Gene ID: 105722, updated on 21-May-2016
Official Symbol
Ano6provided by MGI
Official Full Name
anoctamin 6provided by MGI
Primary source
MGI:MGI:2145890
See related
Ensembl:ENSMUSG00000064210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem16f; AA407480; AW554778; 2900059G15Rik; F730003B03Rik
Orthologs
Location:
15; 15 F1
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (95790843..95975472)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (95621274..95805205)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6961 Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene RIKEN cDNA A130051J0 gene Neighboring gene uncharacterized LOC102634389 Neighboring gene predicted gene 8849 Neighboring gene predicted gene, 41389 Neighboring gene nuclear receptor coactivator 2 pseudogene Neighboring gene nuclear receptor coactivator 2 pseudogene Neighboring gene predicted gene, 38469 Neighboring gene RIKEN cDNA 2610037D02 gene Neighboring gene eukaryotic translation initiation factor 3, subunit I pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
activation of blood coagulation via clotting cascade ISO
Inferred from Sequence Orthology
more info
 
bleb assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
bleb assembly ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium activated galactosylceramide scrambling IDA
Inferred from Direct Assay
more info
PubMed 
calcium activated phosphatidylcholine scrambling IDA
Inferred from Direct Assay
more info
PubMed 
calcium activated phosphatidylserine scrambling IDA
Inferred from Direct Assay
more info
PubMed 
calcium activated phospholipid scrambling IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cation transport ISO
Inferred from Sequence Orthology
more info
 
chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
chloride transport ISO
Inferred from Sequence Orthology
more info
 
dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell volume ISO
Inferred from Sequence Orthology
more info
 
NOT phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylserine exposure on blood platelet ISO
Inferred from Sequence Orthology
more info
 
phospholipid scrambling IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
 
pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of potassium ion export ISO
Inferred from Sequence Orthology
more info
 
purinergic nucleotide receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
purinergic nucleotide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
chloride channel complex ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
anoctamin-6
Names
SCAN channel
small-conductance calcium-activated nonselective cation channel
transmembrane protein 16F

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253813.1NP_001240742.1  anoctamin-6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK159411, BC060732, BE853067, BY717873
    UniProtKB/Swiss-Prot
    Q6P9J9
    Conserved Domains (1) summary
    pfam04547
    Location:309894
    Anoctamin; Calcium-activated chloride channel
  2. NM_175344.4NP_780553.2  anoctamin-6 isoform 2

    See identical proteins and their annotated locations for NP_780553.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC060732, BE853067, BY717873
    Consensus CDS
    CCDS37184.1
    UniProtKB/Swiss-Prot
    Q6P9J9
    Related
    ENSMUSP00000071770, ENSMUST00000071874
    Conserved Domains (1) summary
    pfam04547
    Location:288873
    Anoctamin; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    95790843..95975472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520231.2XP_006520294.1  

    Conserved Domains (1) summary
    pfam04547
    Location:295880
    Anoctamin; Calcium-activated chloride channel
  2. XM_006520233.2XP_006520296.1  

    Conserved Domains (1) summary
    pfam04547
    Location:274859
    Anoctamin; Calcium-activated chloride channel
  3. XM_006520232.2XP_006520295.1  

    Conserved Domains (1) summary
    pfam04547
    Location:290875
    Anoctamin; Calcium-activated chloride channel
  4. XM_006520234.2XP_006520297.2  

    Conserved Domains (1) summary
    pfam04547
    Location:276861
    Anoctamin; Calcium-activated chloride channel

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    97939179..98119566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)