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TOP1 DNA topoisomerase I [ Aotus nancymaae (Ma's night monkey) ]

Gene ID: 105719129, updated on 12-Apr-2024

Summary

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Gene symbol
TOP1
Gene description
DNA topoisomerase I
See related
Ensembl:ENSANAG00000036348
Gene type
protein coding
RefSeq status
MODEL
Organism
Aotus nancymaae
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae; Aotus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_04 current 86718_ANA_hifiasm-v0.15.2.pri (GCF_030222135.1) Unplaced Scaffold NW_026988442.1 (20643248..20742732)
101 previous assembly Anan_2.0 (GCF_000952055.2) Unplaced Scaffold NW_018506828.1 (20463288..20558005)

NW_026988442.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135276929 Neighboring gene U2 spliceosomal RNA Neighboring gene phospholipase C gamma 1 Neighboring gene zinc fingers and homeoboxes 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 1
Names
topoisomerase (DNA) I

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030222135.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

Genomic

  1. NW_026988442.1 Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

    Range
    20643248..20742732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012455015.2 → XP_012310438.1  DNA topoisomerase 1

    See identical proteins and their annotated locations for XP_012310438.1

    UniProtKB/TrEMBL
    A0A2K5EX43
    Related
    ENSANAP00000037728.1
    Conserved Domains (4) summary
    smart00435
    Location:362 → 739
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:218 → 432
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:434 → 637
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:697 → 765
    Topo_C_assoc; C-terminal topoisomerase domain
Nucleotide Protein
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