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ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [ Homo sapiens (human) ]

Gene ID: 10564, updated on 29-Jul-2014
Official Symbol
ARFGEF2provided by HGNC
Official Full Name
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)provided by HGNC
Primary source
HGNC:15853
See related
Ensembl:ENSG00000124198; HPRD:09250; MIM:605371; Vega:OTTHUMG00000032687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIG2; PVNH2; dJ1164I10.1
Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
See ARFGEF2 in Epigenomics, MapViewer
Location:
20q13.13
Exon count:
39
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (48921713..49036693)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47538250..47653230)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723460 Neighboring gene phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Neighboring gene uncharacterized LOC102723483 Neighboring gene synaptosomal-associated protein, 23kDa pseudogene Neighboring gene CSE1 chromosome segregation 1-like (yeast)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2; BIG2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
    Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ARF guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
GABA receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
myosin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endomembrane system organization IMP
Inferred from Mutant Phenotype
more info
 
endosome organization IMP
Inferred from Mutant Phenotype
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
symmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 2
Names
brefeldin A-inhibited guanine nucleotide-exchange protein 2
brefeldin A-inhibited GEP 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011490.1 

    Range
    5001..119956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006420.2NP_006411.2  brefeldin A-inhibited guanine nucleotide-exchange protein 2

    See proteins identical to NP_006411.2

    Status: REVIEWED

    Source sequence(s)
    AB209397, AK074303, AL121903, BC050449
    Consensus CDS
    CCDS13411.1
    UniProtKB/TrEMBL
    Q59FR3
    UniProtKB/TrEMBL
    Q86TH5
    UniProtKB/Swiss-Prot
    Q9Y6D5
    Related
    ENSP00000360985, OTTHUMP00000031231, ENST00000371917, OTTHUMT00000079627
    Conserved Domains (4) summary
    pfam09324
    Location:11661251
    Blast Score: 319
    DUF1981; Domain of unknown function (DUF1981)
    PLN03076
    Location:111711
    Blast Score: 2742
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    cd00171
    Location:643827
    Blast Score: 712
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam12783
    Location:367530
    Blast Score: 520
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    48921713..49036693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260252.1XP_005260309.1  

    Conserved Domains (4) summary
    pfam09324
    Location:11651250
    Blast Score: 320
    DUF1981; Domain of unknown function (DUF1981)
    PLN03076
    Location:111710
    Blast Score: 2741
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    cd00171
    Location:642826
    Blast Score: 712
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    pfam12783
    Location:366529
    Blast Score: 520
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  2. XM_006723683.1XP_006723746.1  

    Conserved Domains (3) summary
    pfam09324
    Location:558643
    Blast Score: 318
    DUF1981; Domain of unknown function (DUF1981)
    PLN03076
    Location:111103
    Blast Score: 1872
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    cd00171
    Location:35219
    Blast Score: 708
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    44289793..44403088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    47442300..47557463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)