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NSD2 nuclear receptor binding SET domain protein 2 [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105585483, updated on 13-Mar-2024

Summary

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Gene symbol
NSD2
Gene description
nuclear receptor binding SET domain protein 2
See related
Ensembl:ENSCATG00000013442
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Also known as
WHSC1
Orthologs
human mouse all
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Genomic context

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See NSD2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012009359.1 (5412252..5495451, complement)

NW_012009359.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105585479 Neighboring gene negative elongation factor complex member A Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene fibroblast growth factor receptor 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012009359.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase NSD2
Names
Wolf-Hirschhorn syndrome candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012009359.1 Reference Caty_1.0

    Range
    5412252..5495451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012059246.1 → XP_011914636.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A2K5KSB3, A0A2K5KSC7
    Related
    ENSCATP00000003591.1, ENSCATT00000015486.1
    Conserved Domains (11) summary
    cd05837
    Location:218 → 337
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:878 → 972
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1012 → 1062
    AWS; associated with SET domains
    smart00317
    Location:1063 → 1186
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5034
    Location:546 → 710
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:458 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:669 → 711
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:716 → 762
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:763 → 816
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:833 → 873
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1241 → 1283
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

  2. XM_012059247.1 → XP_011914637.1  histone-lysine N-methyltransferase NSD2 isoform X2

    UniProtKB/TrEMBL
    A0A2K5KSB3
    Conserved Domains (10) summary
    cd05837
    Location:218 → 337
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:809 → 903
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:943 → 993
    AWS; associated with SET domains
    smart00317
    Location:994 → 1117
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:458 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:600 → 642
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:647 → 693
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:694 → 747
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:764 → 804
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1172 → 1214
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)

  3. XM_012059249.1 → XP_011914639.1  histone-lysine N-methyltransferase NSD2 isoform X3

    UniProtKB/TrEMBL
    A0A2K5KSB3
    Conserved Domains (7) summary
    cd05838
    Location:555 → 649
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:689 → 739
    AWS; associated with SET domains
    smart00317
    Location:740 → 863
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5034
    Location:223 → 387
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:135 → 184
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15654
    Location:440 → 493
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:918 → 960
    PHD_SF; PHD finger superfamily

  4. XM_012059250.1 → XP_011914640.1  histone-lysine N-methyltransferase NSD2 isoform X4

    UniProtKB/TrEMBL
    A0A2K5KSB8
    Related
    ENSCATP00000003607.1, ENSCATT00000015534.1
    Conserved Domains (2) summary
    cd05837
    Location:218 → 337
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:458 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Nucleotide Protein
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