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WNK1 WNK lysine deficient protein kinase 1 [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105582948, updated on 13-Mar-2024

Summary

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Gene symbol
WNK1
Gene description
WNK lysine deficient protein kinase 1
See related
Ensembl:ENSCATG00000042502
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
33
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012007478.1 (784710..941217)

NW_012007478.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 3 Neighboring gene ninjurin 2 Neighboring gene uncharacterized LOC105582944 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene uncharacterized LOC105582956

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012007478.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chloride channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase WNK1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012007478.1 Reference Caty_1.0

    Range
    784710..941217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012054049.1 → XP_011909439.1  serine/threonine-protein kinase WNK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. XM_012054052.1 → XP_011909442.1  serine/threonine-protein kinase WNK1 isoform X4

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  3. XM_012054051.1 → XP_011909441.1  serine/threonine-protein kinase WNK1 isoform X3

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  4. XM_012054053.1 → XP_011909443.1  serine/threonine-protein kinase WNK1 isoform X5

    UniProtKB/TrEMBL
    A0A2K5NQY1, A0A2K5NQZ8
    Related
    ENSCATP00000039939.1, ENSCATT00000064253.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  5. XM_012054055.1 → XP_011909445.1  serine/threonine-protein kinase WNK1 isoform X7

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  6. XM_012054056.1 → XP_011909446.1  serine/threonine-protein kinase WNK1 isoform X8

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  7. XM_012054057.1 → XP_011909447.1  serine/threonine-protein kinase WNK1 isoform X9

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  8. XM_012054054.1 → XP_011909444.1  serine/threonine-protein kinase WNK1 isoform X6

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  9. XM_012054059.1 → XP_011909449.1  serine/threonine-protein kinase WNK1 isoform X11

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  10. XM_012054060.1 → XP_011909450.1  serine/threonine-protein kinase WNK1 isoform X12

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  11. XM_012054061.1 → XP_011909451.1  serine/threonine-protein kinase WNK1 isoform X13

    UniProtKB/TrEMBL
    A0A2K5NQY6, A0A2K5NQZ8
    Related
    ENSCATP00000039943.1, ENSCATT00000064257.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  12. XM_012054062.1 → XP_011909452.1  serine/threonine-protein kinase WNK1 isoform X14

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  13. XM_012054063.1 → XP_011909453.1  serine/threonine-protein kinase WNK1 isoform X15

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Related
    ENSCATP00000039954.1, ENSCATT00000064268.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  14. XM_012054050.1 → XP_011909440.1  serine/threonine-protein kinase WNK1 isoform X2

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  15. XM_012054066.1 → XP_011909456.1  serine/threonine-protein kinase WNK1 isoform X17

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  16. XM_012054069.1 → XP_011909459.1  serine/threonine-protein kinase WNK1 isoform X20

    UniProtKB/TrEMBL
    A0A2K5NR03, A0A2K5NRD3
    Related
    ENSCATP00000039945.1, ENSCATT00000064259.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  17. XM_012054070.1 → XP_011909460.1  serine/threonine-protein kinase WNK1 isoform X21

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  18. XM_012054072.1 → XP_011909462.1  serine/threonine-protein kinase WNK1 isoform X23

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  19. XM_012054076.1 → XP_011909466.1  serine/threonine-protein kinase WNK1 isoform X27

    UniProtKB/TrEMBL
    A0A2K5NR03, A0A2K5NR40
    Related
    ENSCATP00000039947.1, ENSCATT00000064261.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  20. XM_012054073.1 → XP_011909463.1  serine/threonine-protein kinase WNK1 isoform X24

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  21. XM_012054077.1 → XP_011909467.1  serine/threonine-protein kinase WNK1 isoform X28

    UniProtKB/TrEMBL
    A0A2K5NR03
    Related
    ENSCATP00000039958.1, ENSCATT00000064272.1
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  22. XM_012054067.1 → XP_011909457.1  serine/threonine-protein kinase WNK1 isoform X18

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  23. XM_012054074.1 → XP_011909464.1  serine/threonine-protein kinase WNK1 isoform X25

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  24. XM_012054078.1 → XP_011909468.1  serine/threonine-protein kinase WNK1 isoform X29

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  25. XM_012054068.1 → XP_011909458.1  serine/threonine-protein kinase WNK1 isoform X19

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  26. XM_012054075.1 → XP_011909465.1  serine/threonine-protein kinase WNK1 isoform X26

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  27. XM_012054058.1 → XP_011909448.1  serine/threonine-protein kinase WNK1 isoform X10

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  28. XM_012054071.1 → XP_011909461.1  serine/threonine-protein kinase WNK1 isoform X22

    UniProtKB/TrEMBL
    A0A2K5NR03
    Conserved Domains (3) summary
    smart00220
    Location:227 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:196 → 484
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:501 → 538
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  29. XM_012054065.1 → XP_011909455.1  serine/threonine-protein kinase WNK1 isoform X16

    UniProtKB/TrEMBL
    A0A2K5NQZ8
    Conserved Domains (3) summary
    pfam12202
    Location:94 → 131
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:23 → 77
    PKc_like; Protein Kinases, catalytic domain
    cl23716
    Location:925 → 997
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
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