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WRN WRN RecQ like helicase [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105579125, updated on 13-Mar-2024

Summary

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Gene symbol
WRN
Gene description
WRN RecQ like helicase
See related
Ensembl:ENSCATG00000040557
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
37
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012005823.1 (4926459..5067619, complement)

NW_012005823.1Genomic Context describing neighboring genes Neighboring gene neuregulin 1 Neighboring gene BTB/POZ domain-containing protein KCTD9 pseudogene Neighboring gene acyl-CoA:lysophosphatidylglycerol acyltransferase 1-like Neighboring gene purine rich element binding protein G

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012005823.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome RecQ like helicase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012005823.1 Reference Caty_1.0

    Range
    4926459..5067619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012045555.1 → XP_011900945.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900945.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Related
    ENSCATP00000035382.1, ENSCATT00000059664.1
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  2. XM_012045556.1 → XP_011900946.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900946.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  3. XM_012045552.1 → XP_011900942.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900942.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Related
    ENSCATP00000035380.1, ENSCATT00000059662.1
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  4. XM_012045557.1 → XP_011900947.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900947.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  5. XM_012045554.1 → XP_011900944.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900944.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  6. XM_012045553.1 → XP_011900943.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900943.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  7. XM_012045559.1 → XP_011900949.1  Werner syndrome ATP-dependent helicase isoform X1

    See identical proteins and their annotated locations for XP_011900949.1

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDH2
    Related
    ENSCATP00000035398.1, ENSCATT00000059680.1
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  8. XM_012045561.1 → XP_011900951.1  Werner syndrome ATP-dependent helicase isoform X3

    UniProtKB/TrEMBL
    A0A2K5ND05
    Conserved Domains (8) summary
    smart00341
    Location:999 → 1077
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:385 → 858
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    smart00956
    Location:806 → 899
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:607 → 715
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:398 → 559
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1109 → 1199
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:720 → 787
    RecQ_Zn_bind; RecQ zinc-binding
    cl10012
    Location:1 → 104
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  9. XM_012045558.1 → XP_011900948.1  Werner syndrome ATP-dependent helicase isoform X2

    UniProtKB/TrEMBL
    A0A2K5ND05, A0A2K5NDJ2
    Related
    ENSCATP00000035400.1, ENSCATT00000059682.1
    Conserved Domains (8) summary
    smart00341
    Location:1124 → 1202
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:1234 → 1324
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding

  10. XM_012045562.1 → XP_011900952.1  Werner syndrome ATP-dependent helicase isoform X4

    Conserved Domains (6) summary
    TIGR00614
    Location:510 → 983
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:931 → 1024
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:732 → 840
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:523 → 684
    DEAD; DEAD/DEAH box helicase
    pfam16124
    Location:845 → 912
    RecQ_Zn_bind; RecQ zinc-binding
Nucleotide Protein
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