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RPP30 ribonuclease P/MRP subunit p30 [ Homo sapiens (human) ]

Gene ID: 10556, updated on 12-May-2016
Official Symbol
RPP30provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p30provided by HGNC
Primary source
HGNC:HGNC:17688
See related
Ensembl:ENSG00000148688 HPRD:09359; MIM:606115; Vega:OTTHUMG00000018733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG15
Orthologs
Location:
10q23.31
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (90871952..90908558)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92631709..92668312)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926942 Neighboring gene 5-hydroxytryptamine receptor 7 Neighboring gene ankyrin repeat domain 1 Neighboring gene uncharacterized LOC105378427

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
  • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
    tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
tRNA 5'-leader removal TAS
Traceable Author Statement
more info
 
tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
nucleolar ribonuclease P complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
ribonuclease P protein subunit p30
Names
RNase P subunit 2
RNaseP protein p30
ribonuclease P/MRP 30kDa subunit
NP_001098016.1
NP_006404.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104546.1NP_001098016.1  ribonuclease P protein subunit p30 isoform a

    See identical proteins and their annotated locations for NP_001098016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK095810, BC044601, BM978236, DB049454, U77665
    Consensus CDS
    CCDS44458.1
    UniProtKB/Swiss-Prot
    P78346
    Conserved Domains (2) summary
    pfam01876
    Location:74224
    RNase_P_p30; RNase P subunit p30
    pfam13900
    Location:270299
    GVQW; Putative binding domain
  2. NM_006413.4NP_006404.1  ribonuclease P protein subunit p30 isoform b

    See identical proteins and their annotated locations for NP_006404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL833628, DB049454, U77665
    Consensus CDS
    CCDS7411.1
    UniProtKB/Swiss-Prot
    P78346
    Related
    ENSP00000360768, OTTHUMP00000020081, ENST00000371703, OTTHUMT00000049347
    Conserved Domains (1) summary
    pfam01876
    Location:74224
    RNase_P_p30; RNase P subunit p30

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    90871952..90908558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539120.1XP_011537422.1  

    See identical proteins and their annotated locations for XP_011537422.1

    UniProtKB/Swiss-Prot
    P78346
    Conserved Domains (2) summary
    pfam01876
    Location:74224
    RNase_P_p30; RNase P subunit p30
    pfam13900
    Location:270299
    GVQW; Putative binding domain
  2. XM_011539121.1XP_011537423.1  

    See identical proteins and their annotated locations for XP_011537423.1

    UniProtKB/Swiss-Prot
    P78346
    Related
    ENSP00000389182, ENST00000413330
    Conserved Domains (2) summary
    pfam01876
    Location:74224
    RNase_P_p30; RNase P subunit p30
    pfam13900
    Location:270299
    GVQW; Putative binding domain
  3. XM_011539122.1XP_011537424.1  

    Conserved Domains (2) summary
    pfam01876
    Location:74214
    RNase_P_p30; RNase P subunit p30
    pfam13900
    Location:260289
    GVQW; Putative binding domain
  4. XM_011539123.1XP_011537425.1  

    Related
    ENSP00000277882, OTTHUMP00000020082, ENST00000277882, OTTHUMT00000049350
    Conserved Domains (1) summary
    pfam01876
    Location:74224
    RNase_P_p30; RNase P subunit p30

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    92909555..92946159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)