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NRG1 neuregulin 1 [ Mandrillus leucophaeus (drill) ]

Gene ID: 105537989, updated on 13-Mar-2024

Summary

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Gene symbol
NRG1
Gene description
neuregulin 1
See related
Ensembl:ENSMLEG00000034456
Gene type
protein coding
RefSeq status
MODEL
Organism
Mandrillus leucophaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
100 current Mleu.le_1.0 (GCF_000951045.1) Unplaced Scaffold NW_012101843.1 (268512..1482430, complement)

NW_012101843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105537988 Neighboring gene BTB/POZ domain-containing protein KCTD9 pseudogene Neighboring gene WRN RecQ like helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012101843.1 Unplaced Scaffold Reference Mleu.le_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemorepellent activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pro-neuregulin-1, membrane-bound isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mleu.le_1.0

Genomic

  1. NW_012101843.1 Reference Mleu.le_1.0

    Range
    268512..1482430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011977713.1 → XP_011833103.1  pro-neuregulin-1, membrane-bound isoform isoform X11

    See identical proteins and their annotated locations for XP_011833103.1

    Conserved Domains (3) summary
    PHA03099
    Location:182 → 271
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:264 → 421
    Neuregulin; Neuregulin family
    cd05895
    Location:37 → 129
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  2. XM_011977712.1 → XP_011833102.1  pro-neuregulin-1, membrane-bound isoform isoform X10

    See identical proteins and their annotated locations for XP_011833102.1

    UniProtKB/TrEMBL
    A0A2K5YYT6
    Related
    ENSMLEP00000020722.1, ENSMLET00000044221.1
    Conserved Domains (4) summary
    PHA03099
    Location:182 → 274
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    cd00054
    Location:190 → 222
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02158
    Location:267 → 424
    Neuregulin; Neuregulin family
    cd05895
    Location:37 → 129
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  3. XM_011977714.1 → XP_011833104.1  pro-neuregulin-1, membrane-bound isoform isoform X12

    See identical proteins and their annotated locations for XP_011833104.1

    UniProtKB/TrEMBL
    A0A2K5YYH8
    Related
    ENSMLEP00000020596.1, ENSMLET00000044094.1
    Conserved Domains (3) summary
    PHA03099
    Location:28 → 120
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    cd00054
    Location:36 → 68
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02158
    Location:113 → 270
    Neuregulin; Neuregulin family

  4. XM_011977704.1 → XP_011833094.1  pro-neuregulin-1, membrane-bound isoform isoform X3

    See identical proteins and their annotated locations for XP_011833094.1

    UniProtKB/TrEMBL
    A0A2K5YYQ3, A0A2K5YYT2
    Related
    ENSMLEP00000020713.1, ENSMLET00000044212.1
    Conserved Domains (3) summary
    cd05895
    Location:53 → 127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:190 → 220
    EGF; EGF-like domain
    pfam02158
    Location:272 → 627
    Neuregulin; Neuregulin family

  5. XM_011977705.1 → XP_011833095.1  pro-neuregulin-1, membrane-bound isoform isoform X4

    See identical proteins and their annotated locations for XP_011833095.1

    UniProtKB/TrEMBL
    A0A2K5YYQ3, A0A2K5YYS5
    Related
    ENSMLEP00000020714.1, ENSMLET00000044213.1
    Conserved Domains (4) summary
    cd05895
    Location:53 → 127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:182 → 274
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:190 → 220
    EGF; EGF-like domain
    pfam02158
    Location:267 → 622
    Neuregulin; Neuregulin family

  6. XM_011977706.1 → XP_011833096.1  pro-neuregulin-1, membrane-bound isoform isoform X5

    See identical proteins and their annotated locations for XP_011833096.1

    UniProtKB/TrEMBL
    A0A2K5YYQ3, A0A2K5YYS9
    Related
    ENSMLEP00000020717.1, ENSMLET00000044216.1
    Conserved Domains (4) summary
    cd05895
    Location:53 → 127
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    PHA03099
    Location:182 → 271
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:190 → 220
    EGF; EGF-like domain
    pfam02158
    Location:264 → 619
    Neuregulin; Neuregulin family

  7. XM_011977710.1 → XP_011833100.1  pro-neuregulin-1, membrane-bound isoform isoform X9

    See identical proteins and their annotated locations for XP_011833100.1

    UniProtKB/TrEMBL
    A0A2K5YYN1, A0A2K5YYQ3
    Related
    ENSMLEP00000020655.1, ENSMLET00000044153.1
    Conserved Domains (3) summary
    cd05895
    Location:32 → 106
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:135 → 165
    EGF; EGF-like domain
    pfam02158
    Location:185 → 578
    Neuregulin; Neuregulin family

  8. XM_011977709.1 → XP_011833099.1  pro-neuregulin-1, membrane-bound isoform isoform X8

    See identical proteins and their annotated locations for XP_011833099.1

    UniProtKB/TrEMBL
    A0A2K5YYQ3
    Conserved Domains (3) summary
    cd05895
    Location:32 → 106
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:152 → 182
    EGF; EGF-like domain
    pfam02158
    Location:202 → 595
    Neuregulin; Neuregulin family

  9. XM_011977708.1 → XP_011833098.1  pro-neuregulin-1, membrane-bound isoform isoform X7

    See identical proteins and their annotated locations for XP_011833098.1

    UniProtKB/TrEMBL
    A0A2K5YYQ3
    Conserved Domains (3) summary
    cd05895
    Location:32 → 106
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:169 → 199
    EGF; EGF-like domain
    pfam02158
    Location:219 → 612
    Neuregulin; Neuregulin family

  10. XM_011977707.1 → XP_011833097.1  pro-neuregulin-1, membrane-bound isoform isoform X6

    UniProtKB/TrEMBL
    A0A2K5YYQ3
    Related
    ENSMLEP00000020694.1, ENSMLET00000044192.1
    Conserved Domains (4) summary
    cd05895
    Location:60 → 134
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    smart00410
    Location:50 → 136
    IG_like; Immunoglobulin like
    pfam00008
    Location:180 → 210
    EGF; EGF-like domain
    pfam02158
    Location:230 → 623
    Neuregulin; Neuregulin family

  11. XM_011977702.1 → XP_011833092.1  pro-neuregulin-1, membrane-bound isoform isoform X1

    See identical proteins and their annotated locations for XP_011833092.1

    Conserved Domains (2) summary
    pfam00008
    Location:257 → 287
    EGF; EGF-like domain
    pfam02158
    Location:339 → 694
    Neuregulin; Neuregulin family

  12. XM_011977703.1 → XP_011833093.1  pro-neuregulin-1, membrane-bound isoform isoform X2

    See identical proteins and their annotated locations for XP_011833093.1

    Conserved Domains (2) summary
    pfam00008
    Location:257 → 287
    EGF; EGF-like domain
    pfam02158
    Location:334 → 689
    Neuregulin; Neuregulin family

  13. XM_011977715.1 → XP_011833105.1  pro-neuregulin-1, membrane-bound isoform isoform X13

    See identical proteins and their annotated locations for XP_011833105.1

    UniProtKB/TrEMBL
    A0A2K5YYV1
    Related
    ENSMLEP00000020733.1, ENSMLET00000044232.1
    Conserved Domains (1) summary
    PHA02887
    Location:248 → 291
    PHA02887; EGF-like protein; Provisional

  14. XM_011977716.1 → XP_011833106.1  pro-neuregulin-1, membrane-bound isoform isoform X14

    Conserved Domains (2) summary
    smart00410
    Location:43 → 129
    IG_like; Immunoglobulin like
    cl11960
    Location:53 → 127
    Ig; Immunoglobulin domain
Nucleotide Protein
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