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MACF1 microtubule actin crosslinking factor 1 [ Colobus angolensis palliatus ]

Gene ID: 105521421, updated on 13-Mar-2024

Summary

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Gene symbol
MACF1
Gene description
microtubule actin crosslinking factor 1
See related
Ensembl:ENSCANG00000035911
Gene type
protein coding
RefSeq status
MODEL
Organism
Colobus angolensis palliatus (sub-species: palliatus)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
92
Annotation release Status Assembly Chr Location
100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012117376.1 (715230..1161890, complement)

NW_012117376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105521420 Neighboring gene bone morphogenetic protein 8B-like Neighboring gene uncharacterized LOC105521176 Neighboring gene KIAA0754 ortholog Neighboring gene ubiquitin-40S ribosomal protein S27a Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene akirin 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012117376.1 Unplaced Scaffold Reference Cang.pa_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of microtubule-based process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microtubule-actin cross-linking factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cang.pa_1.0

Genomic

  1. NW_012117376.1 Reference Cang.pa_1.0

    Range
    715230..1161890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011955644.1 → XP_011811034.1  microtubule-actin cross-linking factor 1

    UniProtKB/TrEMBL
    A0A2K5J9H4
    Related
    ENSCANP00000025422.1, ENSCANT00000048425.1
    Conserved Domains (8) summary
    smart00243
    Location:5134 → 5206
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:4901 → 5025
    SPEC; Spectrin repeats
    cd00014
    Location:79 → 181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:5059 → 5121
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:4239 → 4455
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07793
    Location:1595 → 1814
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:5060 → 5120
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:3033 → 3248
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein
Heading Accession and Version

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