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NLRP12 NLR family pyrin domain containing 12 [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105497023, updated on 13-Mar-2024

Summary

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Gene symbol
NLRP12
Gene description
NLR family pyrin domain containing 12
See related
Ensembl:ENSMNEG00000035386
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NLRP12 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012011911.1 (1568384..1609212)

NW_012011911.1Genomic Context describing neighboring genes Neighboring gene protein kinase C gamma Neighboring gene myeloid associated differentiation marker Neighboring gene uncharacterized LOC105497024 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012011911 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to cytokine stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MHC class I biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012011911.1 Reference Mnem_1.0

    Range
    1568384..1609212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011767691.2 → XP_011765993.2  NACHT, LRR and PYD domains-containing protein 12 isoform X2

    UniProtKB/TrEMBL
    A0A2K6CIX6
    Related
    ENSMNEP00000023611.1, ENSMNET00000047877.1
    Conserved Domains (5) summary
    cd08320
    Location:13 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:716 → 744
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:213 → 380
    NACHT; NACHT domain
    pfam14484
    Location:129 → 200
    FISNA; Fish-specific NACHT associated domain
    cl26161
    Location:705 → 922
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_011767692.2 → XP_011765994.1  NACHT, LRR and PYD domains-containing protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A2K6CIW6
    Related
    ENSMNEP00000023610.1, ENSMNET00000047876.1
    Conserved Domains (6) summary
    COG4886
    Location:711 → 853
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:705 → 976
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:13 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:715 → 743
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:213 → 380
    NACHT; NACHT domain
    pfam14484
    Location:129 → 200
    FISNA; Fish-specific NACHT associated domain
Nucleotide Protein
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