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PRKN parkin RBR E3 ubiquitin protein ligase [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105487519, updated on 13-Mar-2024

Summary

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Gene symbol
PRKN
Gene description
parkin RBR E3 ubiquitin protein ligase
See related
Ensembl:ENSMNEG00000027725
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
PARK2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012011000.1 (647685..2063109, complement)

NW_012011000.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC112427696 Neighboring gene uncharacterized LOC105487518 Neighboring gene uncharacterized LOC105487517 Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene uncharacterized LOC105487514 Neighboring gene keratin, type II cytoskeletal 8 pseudogene Neighboring gene parkin coregulated Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012011000 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase parkin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012011000.1 Reference Mnem_1.0

    Range
    647685..2063109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011750979.2 → XP_011749281.1  E3 ubiquitin-protein ligase parkin isoform X2

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (4) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
    smart00647
    Location:312 → 374
    IBR; In Between Ring fingers
    pfam01485
    Location:412 → 452
    IBR; IBR domain, a half RING-finger domain

  2. XM_011750978.2 → XP_011749280.1  E3 ubiquitin-protein ligase parkin isoform X1

    UniProtKB/TrEMBL
    A0A2K6B5N6, A0A2K6B5P1
    Related
    ENSMNEP00000006722.1, ENSMNET00000030813.1
    Conserved Domains (4) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
    smart00647
    Location:313 → 375
    IBR; In Between Ring fingers
    pfam01485
    Location:413 → 453
    IBR; IBR domain, a half RING-finger domain

  3. XM_011750983.2 → XP_011749285.1  E3 ubiquitin-protein ligase parkin isoform X6

    See identical proteins and their annotated locations for XP_011749285.1

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (2) summary
    smart00647
    Location:234 → 296
    IBR; In Between Ring fingers
    pfam01485
    Location:334 → 374
    IBR; IBR domain, a half RING-finger domain

  4. XM_011750986.2 → XP_011749288.1  E3 ubiquitin-protein ligase parkin isoform X6

    See identical proteins and their annotated locations for XP_011749288.1

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (2) summary
    smart00647
    Location:234 → 296
    IBR; In Between Ring fingers
    pfam01485
    Location:334 → 374
    IBR; IBR domain, a half RING-finger domain

  5. XM_011750984.2 → XP_011749286.1  E3 ubiquitin-protein ligase parkin isoform X6

    See identical proteins and their annotated locations for XP_011749286.1

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (2) summary
    smart00647
    Location:234 → 296
    IBR; In Between Ring fingers
    pfam01485
    Location:334 → 374
    IBR; IBR domain, a half RING-finger domain

  6. XM_011750981.2 → XP_011749283.1  E3 ubiquitin-protein ligase parkin isoform X4

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (3) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
    smart00647
    Location:312 → 374
    IBR; In Between Ring fingers

  7. XM_011750980.2 → XP_011749282.1  E3 ubiquitin-protein ligase parkin isoform X3

    UniProtKB/TrEMBL
    A0A2K6B5P1
    Conserved Domains (3) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
    smart00647
    Location:313 → 375
    IBR; In Between Ring fingers

  8. XM_011750982.2 → XP_011749284.1  E3 ubiquitin-protein ligase parkin isoform X5

    UniProtKB/TrEMBL
    A0A2K6B5P6
    Related
    ENSMNEP00000006732.1, ENSMNET00000030830.1
    Conserved Domains (2) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues

  9. XM_011750985.2 → XP_011749287.1  E3 ubiquitin-protein ligase parkin isoform X7

    UniProtKB/TrEMBL
    A0A2K6B5P6
    Conserved Domains (2) summary
    cd01798
    Location:3 → 72
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:1 → 72
    UBQ; Ubiquitin homologues
Nucleotide Protein
Heading Accession and Version

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