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BATF basic leucine zipper ATF-like transcription factor [ Homo sapiens (human) ]

Gene ID: 10538, updated on 8-May-2016
Official Symbol
BATFprovided by HGNC
Official Full Name
basic leucine zipper ATF-like transcription factorprovided by HGNC
Primary source
HGNC:HGNC:958
See related
Ensembl:ENSG00000156127 HPRD:09820; MIM:612476; Vega:OTTHUMG00000171486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFA2; B-ATF; BATF1; SFA-2
Summary
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (75522441..75546992)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75988784..76013335)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Jun dimerization protein 2 Neighboring gene uncharacterized LOC105370572 Neighboring gene uncharacterized LOC102724153 Neighboring gene feline leukemia virus subgroup C cellular receptor family member 2 Neighboring gene ribosomal protein S24 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 17 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 2 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphoid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
basic leucine zipper transcriptional factor ATF-like
Names
B-cell-activating transcription factor
SF-HT-activated gene 2 protein
activating transcription factor B
basic leucine zipper transcription factor, ATF-like

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006399.3NP_006390.1  basic leucine zipper transcriptional factor ATF-like

    See identical proteins and their annotated locations for NP_006390.1

    Status: REVIEWED

    Source sequence(s)
    BC032294, BP235761, U15460
    Consensus CDS
    CCDS9843.1
    UniProtKB/Swiss-Prot
    Q16520
    Related
    ENSP00000286639, OTTHUMP00000246169, ENST00000286639, OTTHUMT00000413669
    Conserved Domains (1) summary
    cd14701
    Location:2683
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    75522441..75546992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    75926564..75951110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)